大毒中药对机体的不良反应和肝脏药物代谢酶调节研究进展  

Research Progress on the Adverse Effects and Regulation of Liver Drug Metabolism Enzymes in the Body of Large Toxic Chinese Medicine

作　　者：吕新[1] 尹航[1] 阎明睿 范晓宇 贾艳艳[1] 姜丽丽[1] 刘勇[1] LYU Xin;YIN Hang;YAN Mingrui;FAN Xiaoyu;JIA Yanyan;JIANG Lili;LIU Yong(School of Life and Medicine,Dalian University of Technology,Panjin 124221,China)

机构地区：[1]大连理工大学生命科学与药学学院,盘锦124221

出　　处：《世界中医药》2020年第23期3593-3598,共6页World Chinese Medicine

基　　金：国家科技部重点研发计划项目(2017YFC1702006)——基于器官芯片技术的中药安全性有效性评价体系。

摘　　要：近十几年来,随着中药在世界的应用范围不断扩大,中华人民共和国药典中所记载的10种大毒中药也逐渐被应用于临床。但人体服用此类药物后,在肝脏药物代谢酶的介导下达到治疗效果的同时,也可能会对代谢酶产生影响,从而造成机体器官的损伤等不良反应,严重时会危及到人的生命。因此,对大毒中药的不良反应和肝脏代谢酶研究极为重要。本文将10种大毒中药国内外的相关研究资料进行总结,为大毒中药的研究和临床的合理应用提供科学依据。In recent decades,with the continuous expansion of the scope of application of Chinese medicine in the world,10 types of large toxic Chinese medicines are recorded in the Chinese Pharmacopoeia and have gradually been used in clinics.However,after taking these drugs,the liver drug-metabolizing enzymes are mediated to achieve the therapeutic effect.The metabolic enzymes are affected,resulting in organ damage and other adverse reactions,which may endanger human life in serious cases.Therefore,it is extremely important to study the adverse reactions of large toxic Chinese medicines and liver metabolic enzymes.This paper summarizes the relevant research data of 10 kinds of large toxic Chinese medicines worldwide,providing scientific basis for the research and reasonable clinical application of large toxic Chinese medicines.

关 键 词：大毒 中药 毒性成分 不良反应 肝脏代谢酶 细胞色素P450酶 尿苷二磷酸-葡萄糖醛酸转移酶 研究进展 

分 类 号：R285[医药卫生—中药学]