术前消癌平干预对原发性肝癌患者肿瘤标志物、抗肿瘤免疫应答及癌基因表达的影响  

Effect of Preoperative Xiao’ai Ping Intervention on Tumor Markers, Anti-tumor Immune Response and Oncogene Expression in Patients with Primary Liver Cancer

作　　者：熊诗峰 杨武[1] XIONG Shi-Feng;YANG Wu(General Surgery Department of Ji'an People's Hospital,Ji'an 343000,China)

机构地区：[1]吉安市中心人民医院急诊外科,江西吉安343000

出　　处：《中国药物经济学》2020年第10期98-101,共4页China Journal of Pharmaceutical Economics

摘　　要：目的探讨术前消癌平干预对原发性肝癌(PHC)患者肿瘤标志物、抗肿瘤免疫应答及癌基因表达的影响。方法选取2015年12月至2018年4月于吉安市中心人民医院接受肝癌切除术的98例PHC患者作为研究对象,根据术前处理方案不同分为对照组(无术前特殊干预、n=50)、消癌平组(接受术前消癌平干预、n=48)。比较两组患者入院即刻(T0)、术前1 d(T1)血清肿瘤标志物、外周血抗肿瘤免疫应答指标水平,测定术中肝癌组织中癌基因表达情况。结果 T0时,两组患者血清肿瘤标志物水平、外周血抗肿瘤免疫应答指标水平比较差异无统计学意义(P>0.05)。T1时,消癌平组患者血清甲胎蛋白(AFP)、磷脂酰肌醇蛋白聚糖-3(GPC3)、异常凝血酶原(DCP)水平低于对照组,外周血中CD4+细胞水平高于对照组,CD8+、CD4+CD25+调节性T(Treg)细胞水平低于对照组,差异有统计学意义(P<0.05)。消癌平组患者术中肝癌病灶组织中癌基因Gankyrin、HCCR、FBI-1、Pokemon的m RNA及蛋白表达量显著低于对照组,差异有统计学意义(P<0.05)。结论术前消癌平干预可有效降低PHC恶性程度,可能成为优化治疗结局的可靠手段之一。Objective To investigate the effect of preoperative Xiao’ai Ping intervention on tumor markers, anti-tumor immune response and oncogene expression in patients with primary liver cancer(PHC). Methods A total of ninety-eight PHC patients admitted to Ji’an People’s Hospital undergoing liver cancer resection from December 2015 to April 2018 were divided into a control group(without preoperative special intervention, n=50) and Xiao’ai Ping group(with preoperative Xiao-Ai-Ping intervention, n=48) according to different preoperative treatment plan.(T1) Serum tumor markers, peripheral blood anti-tumor immune response index levels were compared between two groups at the time of admission(T0) and the day before operation(T1);oncogene expression in liver cancer tissues during operation was determined. Results At the time of T0, there were no significant difference in serum tumor markers and peripheral blood anti-tumor immune response index level between two groups(P>0.05). At the time of T1, the levels of serum alpha-fetoprotein(AFP), glypican-3(GPC3) and abnormal prothrombin(DCP) in the Xiao’aiping group were lower than those in the control group, the levels of CD4+ cells in peripheral blood were higher than those of control group, and CD4+ cell level in peripheral blood were lower than those of control group(P<0.05). The mRNA and protein expression of Gankyrin, HCCR, FBI-1, Pokemon in the liver cancer lesion tissue of patients in the Xiao’ai Ping group were significantly lower than those of control group(P<0.05). Conclusion Preoperative Xiao’ai Ping intervention can effectively reduce the malignant degree of PHC, and may be one of the reliable means to optimize the outcome of treatment.

关 键 词：原发性肝癌 消癌平 肿瘤标志物 抗肿瘤免疫应答 癌基因 

分 类 号：R735.7[医药卫生—肿瘤] R287[医药卫生—临床医学]