生物类与非生物类图片命名任务对大脑活动时空模式的影响  

Effects of life and nonlife picture naming tasks on the spatio-temporal patterns of brain activity

作　　者：蒋玉尔 林枫[1,2] 江钟立 Jiang Yuer;Lin Feng;Jiang Zhongli(The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China)

机构地区：[1]南京医科大学第一附属医院(江苏省人民医院)康复医学科,南京210029 [2]南京医科大学附属逸夫医院康复医学科,南京211100

出　　处：《中国康复》2020年第12期619-624,共6页Chinese Journal of Rehabilitation

基　　金：国家自然科学基金资助项目(81672255);江苏省科技支撑计划(BE2012675);江苏省高校哲学社会科学优秀创新团队建设项目资助(2017STD006);南京医科大学附属逸夫医院院内临床重点科室建设专项(YFZDXK02-7)。

摘　　要：目的:探讨图片的语义类别对命名任务的影响,研究生物类和非生物类图片命名任务对正常大脑活动时空模式的影响。方法:入组健康成年右利手受试者10例,选取来自不同语义类别(生物类和非生物类)的图片20张,应用磁共振成像获取个体大脑结构,脑磁图(MEG)检测任务中的全脑活动。结果:在图片命名任务中,早期脑区激活从双侧枕叶开始,逐步向颞叶和顶叶扩散,最后额叶激活产生言语。在视觉相关时间窗内,生物类图片命名在右侧扣带回激活强度显著低于非生物类图片命名(P=0.0475),而生物类图片命名在双侧枕叶、左侧顶叶和左侧额叶均显著高于非生物类图片命名(均P<0.05)。在语义相关时间窗内,生物类图片命名在双侧额叶显著高于非生物类图片命名(P<0.05)。在语音相关时间窗内,生物类图片命名在双侧枕叶、左侧顶叶和左侧额叶均显著高于非生物类图片命名(均P<0.05)。结论:生物类和非生物类图片命名相比,两者在颞叶的活动未见显著差异,但前者具有枕叶、顶叶和额叶优势激活。提示生物类图片可以更好地在相关时间窗内刺激相关功能脑区。Objective:To explore the influence of semantic categories during naming task,and study the effects of life and nonlife picture naming tasks on the spatio-temporal patterns of healthy brain activity.Methods:Ten healthy adult right-handed subjects were enrolled.Twenty pictures from different semantic categories(life and nonlife)were selected,and the brain structure of individuals was obtained by magnetic resonance imaging,while the whole brain activity in the picture naming task was detected by magnetoencephalogram(MEG).Results:In the picture naming tasks,early brain activation started in the bilateral occipital lobes,gradually spread to the temporal and parietal lobes,and finally generated the speech production in the frontal lobes.In the visual related time windows,the activation of nonlife categories picture naming in the right cingulate gyrus was significantly greater than the life(P=0.0475),while the activation of life categories in the bilateral occipital lobes,left parietal lobe and left frontal lobe was significantly greater than the nonlife(all P<0.05).In the semantic related time windows,the activation of life categories in the bilateral frontal lobes was significantly greater than nonlife categories(P<0.05).In the phonological related time windows,the activation of life categories in the bilateral occipital lobes,left parietal lobe and left frontal lobe was significantly greater than nonlife categories(all P<0.05).Conclusion:Compared with the picture naming of nonlife categories,naming of life categories had no significant difference in temporal lobe activity but showed a dominant activation in occipital,parietal and frontal lobes,which suggested that picture naming of life categories can stimulate the related functional regions in the related time windows better.

关 键 词：语义类别 图片命名 脑磁图 言语治疗 

分 类 号：R49[医药卫生—康复医学]