维吾尔族妇女局部晚期宫颈鳞癌外周血T细胞亚群与临床特征和预后关系  

Relationship between T cell subsets in peripheral blood and clinical characteristics and prognosis of Uygur women with advanced cervical squamous cell carcinoma

作　　者：郭玉萍[1] 古丽娜·库尔班[1] 王若峥[1] Guo Yuping;Gulina Kulban;Wang Ruozheng(Department of Radiotherapy,Cancer Hospital Affiliated to Xinjiang Medical University,Wulumuqi 830011,China)

机构地区：[1]新疆医科大学附属肿瘤医院放疗科,乌鲁木齐830011

出　　处：《中华放射肿瘤学杂志》2020年第12期1064-1069,共6页Chinese Journal of Radiation Oncology

基　　金：国家自然科学基金(U1603282);中国医学科学院非营利中央研究所基金(2018PT31050)。

摘　　要：目的观察新疆地区维吾尔族局部晚期宫颈鳞癌患者外周血T细胞亚群与临床特征、预后的关系。方法选择2015-2018年间新疆医科大学附属肿瘤医院经组织病理证实的ⅡB-ⅣA期宫颈鳞癌患者185例,回顾性分析外周静脉血T细胞亚群与临床特征及预后的关系。结果CD^+4T细胞、CD^+8T细胞、CD^+4/CD^+8T细胞比值与临床分期、肿瘤最长径、体质量指数(BMI)有关(均P<0.05)。国际妇产科协会(FIGO)分期越晚、最长径越大、BMI越高,CD^+8T细胞越高,CD^+4T细胞、CD^+4/CD^+8T细胞比值越低;淋巴结转移者,CD^+4T细胞减低。单因素分析结果显示FIGO分期、年龄、淋巴结转移、肿瘤最长径、BMI、CD^+4T细胞、CD^+8T细胞、CD^+4/CD^+8T细胞比值及治疗方式是影响局部晚期宫颈鳞癌患者总生存(OS)的重要因素;多因素分析结果显示BMI、治疗方式、CD^+4T细胞及肿瘤最长径是影响患者OS的独立预后因素(均P<0.05)。结论维吾尔族宫颈癌患者外周血T细胞亚群水平失调,CD^+4T细胞、CD^+8T细胞、CD^+4/CD^+8T细胞比值与宫颈癌FIGO分期、肿瘤最长径、BMI有关,CD^+4T细胞还与淋巴结转移相关。BMI、治疗方式、肿瘤最长径及CD^+4T细胞是影响患者OS的独立预后因素。Objective To observe the relationship between peripheral blood T cell subsets and clinical characteristics and prognosis of Uygur women with advanced cervical squamous cell carcinoma in Xinjiang.Methods A total of 185 patients pathologically diagnosed with stageⅡB-IVA cervical squamous cell carcinoma admitted to Cancer Hospital Affiliated to Xinjiang Medical University from January 2015 to December 2018 were selected.The relationship between T cell subsets in peripheral venous blood and clinical characteristics and prognosis was analyzed.Results CD^+4 T cells,CD^+8 T cells and CD^+4/CD^+8 T cell ratio were significantly correlated with clinical stage,tumor diameter and body mass index(BMI)(all P<0.05).The later Federation International Association of Gynecology and Obstetrics(FIGO)tumor stage,the larger the tumor diameter,the higher the BMI,and the higher the CD^+8 T cells and the lower the CD^+4 T cell and CD^+4/CD^+8 T cell ratio.The count of CD^+4 T cells was decreased in patients with lymph node metastasis.Cox’s univariate analysis showed that FIGO stage,age,lymph node metastasis,tumor diameter,BMI,CD^+4 T cells,CD^+8 T cells,CD^+4/CD^+8 T cell ratio and treatment methods were the important factors affecting the overall survival(OS).Multivariate analysis showed that BMI,treatment method,CD^+4T cells and tumor diameter were the independent prognostic factors affecting OS(all P<0.05).Conclusions The level of T cell subsets in peripheral blood of Uygur cervical cancer patients is out of balance.CD^+4T cells,CD^+8 T cells and CD^+4/CD^+8 T cell ratio are associated with FIGO stage,tumor diameter and BMI,and CD^+4 T cells are correlated with lymph node metastasis.BMI,treatment method,tumor diameter and CD^+4 T cell are the independent prognostic factors affecting the OS of patients with cervical cancer.

关 键 词：宫颈癌 CD^+4T细胞 CD^+8T细胞 CD^+4/CD^+8T细胞比值 预后 

分 类 号：R737.33[医药卫生—肿瘤]