热疗对肿瘤免疫微环境中免疫细胞及免疫相关细胞因子的影响  

Effect of hyperthermia on immune cells and immune-related cytokines in tumor immune microenvironment

作　　者：周学筱 沈佩 王升志[2] 石凡 孙巧珍 徐婷[2] Zhou Xuexiao;Shen Pei;Wang Shengzhi;Shi Fan;Sun Qiaozhen;Xu Ting(School of Stomatology of Qingdao University,Qingdao 266003,China;Department of Oral and Maxillofacial Surgery,The Affiliated Yantai Yuhuangding Hospital of Qingdao University,Yantai 264000,China)

机构地区：[1]青岛大学口腔医学院,266003 [2]青岛大学附属烟台毓璜顶医院口腔科,264000

出　　处：《中华放射肿瘤学杂志》2020年第12期1130-1134,共5页Chinese Journal of Radiation Oncology

基　　金：烟台市科技计划项目(2018SFGY106)。

摘　　要：随着对肿瘤热疗和肿瘤免疫微环境(TIME)的深入研究,近年来热疗对TIME的作用越来越受到学者们的重视。本文就目前国内外研究进展,对热疗与TIME中几类主要免疫细胞和免疫相关细胞因子的影响及作用机制作一综述。全面而透彻的了解热疗对TIME的调控作用,有助于为肿瘤治疗提供新的思路和方法。With the in-depth study of tumor hyperthermia and tumor immune microenvironment(TIME),the role of hyperthermia in TIME has captivated increasing attention from scholars in recent years.Based upon recent research progress at home and abroad,the effect and mechanism of hyperthermia on several major immune cells and immune-related cytokines in the TIME were reviewed in this article.Comprehensive and deep understanding of the regulation of hyperthermia on the TIME could provide new ideas and methods for tumor treatment.

关 键 词：肿瘤/热疗法 肿瘤免疫微环境 免疫细胞 细胞因子 热休克蛋白 

分 类 号：R730.5[医药卫生—肿瘤]