醋酸卡泊芬净制备中的杂质结构研究  

Study on Impurity Profiles of Caspofung in Acetate

作　　者：余欢 潘锡霞 张伯引[2] 卢时湧[2] 钱秀萍[1] YU Huan;PAN Xi-xia;ZHANG Bo-yin;LU Shi—yong;QIAN Xiu-ping(School of Pharmacy,Shanghai Jiao Tong University,Shanghai 200240,China;Zhejiang Medicine Co.,Ltd.,Xinchang Pharmaceutical Factory,Xinchang 312500,China)

机构地区：[1]上海交通大学药学院,上海200240 [2]浙江医药股份有限公司新昌制药厂,浙江新昌312500

出　　处：《精细化工中间体》2020年第5期27-31,共5页Fine Chemical Intermediates

摘　　要：介绍了醋酸卡泊芬净制备过程,利用制备型HPLC获取了醋酸卡泊芬净的4个杂质。通过对杂质的HPLC、 HRMS和NMR分析,进行了结构确证。追溯了杂质来源,为产品质量控制提供科学参考。This paper introduced the preparation process of Caspofungin acetate, and four impurities of Caspofungin acetateobtained by pre-HPLC. The structure of impurities was confirmed by HPLC, HRMS and NMR. The impurities sources were investigated and the quality control methods for impurities were established.

关 键 词：醋酸卡泊芬净 杂质谱 结构确证 

分 类 号：TQ465[化学工程—制药化工]