地龙消痫汤联合卡马西平对小儿部分性发作癫痫的临床疗效及对血清钙、磷水平的影响  

Clinical efficacy of Dilong Xiaoxian Tang(地龙消痫汤)combined with carbamazepine on children with partial seizure epilepsy and its effect on serum levels of calcium and phosphorus

作　　者：廖伟荣 李海娇[1] 黄剑 LIAO Weirong;LI Haijiao;HUANG Jian(Department of Pediatrics,Taizhou Traditional Chinese Medicine Hospital,Taizhou,Zhejiang,318000,China)

机构地区：[1]台州市中医院儿科,浙江台州318000

出　　处：《中医儿科杂志》2020年第6期85-88,共4页Journal of Pediatrics of Traditional Chinese Medicine

摘　　要：目的观察地龙消痫汤联合卡马西平治疗小儿部分性发作癫痫的临床疗效及对血清钙、磷水平的影响。方法选取2016年4月至2019年4月台州市中医院儿科门诊收治的67例部分性发作癫痫患儿,按照随机数字表法分为对照组33例和治疗组34例。对照组均予卡马西平口服,治疗组在对照组治疗方法的基础上联合地龙消痫汤治疗,4周为1个疗程,连续治疗4个疗程后,统计2组的临床疗效,癫痫每月发作频率及每次持续时间,血清钙、磷水平以及不良反应发生情况。结果对照组总有效率为75.76%(25/33),治疗组为97.06%(33/34),2组比较,差异有统计学意义(P<0.05)。治疗前2组癫痫每月发作频率及每次持续时间比较,差异无统计学意义(P>0.05),具有可比性;治疗后2组癫痫发作频率显著下降,持续时间明显缩短,与同组治疗前比较,差异均有统计学意义(P<0.05),且治疗组改善更显著(P<0.05)。治疗前2组血清钙、磷水平比较,差异无统计学意义(P>0.05),具有可比性;治疗后2组血清钙、磷水平均显著降低,与同组治疗前比较,差异均有统计学意义(P<0.05),且治疗组降低更显著(P<0.05)。对照组不良反应总发生率为27.27%(9/33),治疗组为2.94%(1/34),2组比较,差异有统计学意义(P<0.05)。结论地龙消痫汤联合卡马西平治疗小儿部分性发作癫痫,能有效减少癫痫发作频率和持续时间,降低血清钙、磷水平,疗效显著,值得在临床推广应用。Objective To observe the clinical efficacy of Dilong Xiaoxian Tang(地龙消痫汤) combined with carbamazepine on children with partial seizure epilepsy and its effect on serum levels of calcium and phosphorus.Methods From April 2016 to April 2019,67 children with partial seizure epilepsy admitted into outpatient service in pediatrics department of Taizhou Traditional Chinese Medicine Hospital were chosen and divided into control group with 33 cases and treatment group with 34 cases according to random number table method.The control group was given oral carbamazepine,on this basis,the treatment group was combined with Dilong Xiaoxian Tang.Four weeks constituted 1 course of treatment,after 4 consecutive courses of treatment,we kept statistics about the clinical efficacy,seizure frequency in every month and duration every time,the serum levels of calcium and phosphorus and incidence of adverse reactions of the 2 groups.Results The total effective rate of the control group was 75.76%(25/33),that of the treatment group was 97.06%(33/34),and the difference between the 2 groups was statistically significant(P<0.05).The difference was not statistically significant in seizure frequency in every month and duration every time between the 2 groups before treatment(P>0.05),and they were comparable.After treatment,the seizure frequency significantly decreased and duration significantly shortened,and the difference was statistically significant compared with the same group before treatment(P<0.05),moreover,the treatment group improved more significantly(P<0.05).The difference was not statistically significant in serum levels of calcium and phosphorus between the 2 groups before treatment(P>0.05),and they were comparable.After treatment,the serum levels of calcium and phosphorus in the 2 groups significantly decreased,and the difference was statistically significant compared with the same group before treatment(P<0.05),moreover,the treatment group decreased more significantly(P<0.05).The total incidence of adverse reactions i

关 键 词：部分性发作癫痫 小儿 卡马西平 地龙消痫汤 血清钙 血清磷 临床观察 

分 类 号：R742.1[医药卫生—神经病学与精神病学]