儿童急性缺血性脑卒中机械取栓研究进展  

Progress of mechanical thrombectomy in children with acute ischemic stroke

作　　者：袁正洲 何莹超 李作孝 Yuan Zhengzhou;He Yingchao;Li Zuoxiao(Department of Neurology,the Affiliated Hospital of Southwest Medical University,Luzhou,Sichuan 646000,China;Department of Neurology,Fujian Provincial Hospital,Fuzhou 350001,China)

机构地区：[1]西南医科大学附属医院神经内科,四川泸州646000 [2]福建省立医院神经内科,福州350001

出　　处：《中华神经科杂志》2020年第12期1068-1072,共5页Chinese Journal of Neurology

摘　　要：机械取栓是治疗成人大血管闭塞所致急性缺血性脑卒中的最有效方法,相较传统疗法,疗效有极大提升。该疗法循证医学证据充足,疗效安全可靠,自2015年起被各国指南推荐,2018年机械取栓时间窗由6 h延长至24 h,让更多的成人急性缺血性脑卒中患者从中获益。但在儿童患者中,由于机械取栓缺乏高质量的临床研究,也没有相应的指南推荐,极大地限制了其在临床中的应用。国际上一些个案报道及少量回顾性研究结果显示机械取栓在儿童中是安全有效的,但也存在一些挑战。本文对儿童取栓的挑战、实施方案等研究进行综述,为临床提供参考。Mechanical thrombectomy is the most effective method for the treatment of adult acute ischemic stroke caused by occlusion of large blood vessels.Compared with traditional therapy,the curative effect is greatly improved.The evidence-based medicine evidence of the treatment is sufficient,and the efficacy is safe and reliable.Since 2015,it has been recommended by the guidelines of various countries.In 2018,the time window of mechanical thrombectomy has been extended from six hours to 24 hours,which benefits more adult patients with acute ischemic stroke.However,due to the lack of high-quality clinical research,there is no corresponding guide recommendation in children,which greatly limits its clinical application.There are some cases of mechanical thrombectomy in children and a few retrospective studies show that it is safe and effective in children in the world,but there are also some challenges.The article reviewed the challenges and implementation plan of thrombectomy in children to provide reference for clinical practice.

关 键 词：儿童 急性缺血性脑卒中 机械取栓 

分 类 号：R743.3[医药卫生—神经病学与精神病学]