基于肿瘤数据库分析SOX基因家族在肝癌中的表达及预后意义  

Analysis of expression and prognostic significance of SOX gene family in liver cancer based on tumor databases

作　　者：余水红[1] 李艳 钱燕[1] 严其高 王晓梅[2] 龚莉 YU Shui-hong;LI Yan;QIAN Yan;YAN Qi-gao;WANG Xiao-mei;GONG Li(Central Lab,Anqing Medical College,Anqing 246052,Anhui Province,China;不详)

机构地区：[1]安庆医药高等专科学校中心实验室,安徽安庆246052 [2]深圳大学医学院,广东深圳518061 [3]安庆师范大学生命科学学院,安徽安庆246052

出　　处：《中国生物制品学杂志》2020年第11期1270-1275,共6页Chinese Journal of Biologicals

基　　金：安徽省高校自然科学研究项目(KJ2018A0932);校级自然重点项目(ZR2019003)。

摘　　要：目的通过肿瘤数据库分析SOX基因家族在肝癌中的表达,及其对肝癌患者预后的影响。方法采用cBioPortal数据库检索分析SOX基因家族中12个基因在肝癌组织中的突变频率及变异情况;利用Ualcan数据库比较分析肝癌组织及癌旁组织中12个基因mRNA的表达;结合Kaplan-Meier plotter数据库的临床信息进一步分析SOX基因家族中12个基因在肝癌患者中潜在的预后价值。结果SOX基因家族大多数成员扩增突变,SOX15为缺失突变。SOX4、SOX8、SOX11、SOX12、SOX15、SOX17、SOX18及SOX21基因在肝癌组织中mRNA表达均高于癌旁组织(P<0.05),SOX1、SOX3、SOX14及SRY基因差异无统计学意义(P>0.05)。SOX1、SOX3、SOX8、SOX14、SOX15、SOX17、SOX18、SOX21及SRY基因在肝癌患者中的表达均上调(HR<1,Logrank P<0.05),利于患者预后;SOX4、SOX11及SOX12基因高表达与患者不良预后相关(HR>1,Logrank P<0.05)。结论SOX基因家族与肝癌发生发展密切相关,大部分成员可作为肿瘤患者的预后标志基因。Objective To analyze the expression of SOX gene family in liver cancer as well as its effect on the prognosis of patients.Methods The mutation frequencies and variations of twelve genes of SOX family in liver cancer tissue were analyzed by using cBioPortal database,while the mRNA expression levels by using Ualcan database.The prognostic significances of twelve genes in liver cancer were further investigated via Kaplan-Meier plotter.Results Amplification mutations of most members of SOX gene family were observed while SOX15 gene was deleted.Compared with those in adjacent tissues,the mRNA expression levels of SOX4,SOX8,SOX11,SOX12,SOX15,SOX17,SOX18 and SOX21 genes in liver cancer tissue increased(P<0.05),while those of SOX1,SOX3,SOX14 and SRY genes showed no significant difference(P>0.05).The expressions of SOX1,SOX3,SOX8,SOX14,SOX15,SOX17,SOX18,SOX21 and SRY genes in liver cancer were up-regulated(HR<1,Logrank P<0.05),which were significantly associated with favorable overall survival.However,the high expressions of SOX4,SOX11 and SSOX12 genes were associated with unfavorable prognosis(HR>1,Logrank P<0.05).Conclusion SOX gene family are closely associated with the onset and progress of liver,of which most members may be used as the potential prognostic biomarkers in patients.

关 键 词：SOX基因家族 肝癌 预后 

分 类 号：R735.7[医药卫生—肿瘤]