阿加曲班与氯吡格雷联合用药方案治疗大动脉粥样硬化性脑梗死的临床疗效及其对血清炎性因子的影响  

Clinical Efficacy of Combination Therapy of Argatroban and Clopidogrel in the Treatment of Atherosclerotic Cerebral Infarction and Its Effect on Serum Inflammatory Factors

作　　者：张冬侠 ZHANG Dongxia(No.2 Department of Neurology,Lingyuan Central Hospital,Lingyuan 122500,China)

机构地区：[1]凌源市中心医院神经二区,辽宁凌源122500

出　　处：《中国医药指南》2020年第32期95-96,共2页Guide of China Medicine

摘　　要：目的分析阿加曲班与氯吡格雷联合用药方案治疗大动脉粥样硬化性脑梗死的临床疗效及其对血清炎性因子的影响。方法选择凌源市中心医院2017年12月至2019年5月收治的大动脉粥样硬化性脑梗死患者66例为研究对象,依据随机数字分组法将其分为对照组、治疗组(每组33例);对照组采用氯吡格雷治疗,治疗组采用阿加曲班与氯吡格雷联合用药治疗。对比两组的神经功能缺损评分、生活能力评分、血清炎性因子水平、临床治疗总有效率、不良反应发生率。结果治疗后,治疗组患者神经功能缺损评分、血清炎性因子水平、生活能力评分、治疗总有效率优于对照组,两组数据比较,有统计学意义(P<0.05);两组患者不良反应发生率无统计学意义。结论大动脉粥样硬化性脑梗死患者应用阿加曲班与氯吡格雷联合用药方案治疗,能改善神经功能缺损情况与血清炎性因子水平,提高治疗效果与患者生活能力。Objective To analyze the clinical effi cacy of argatroban combined with clopidogrel in the treatment of large atherosclerotic cerebral infarction and its eff ect on serum infl ammatory factors.Methods The 66 patients with large atherosclerotic cerebral infarction who were admitted to Lingyuan Central Hospital from December 2017 to May 2019 were selected as the research objects.According to the random number grouping method,they were divided into a control group and a treatment group(33 cases in each group).The control group was treated with clopidogrel,and the treatment group was treated with a combination of argatroban and clopidogrel.The neurological defi cit score,living ability score,serum infl ammatory factor level,total eff ective rate of clinical treatment,and incidence of adverse reactions between the two groups were compared.Results After treatment,the neurological defi cit score,serum infl ammatory factor level,living ability score,and total eff ective rate of treatment in the treatment group were better than those in the control group.The comparison of the data between the two groups was statistically signifi cant(P<0.05);adverse reactions in the two groups the incidence was not statistically significant.Conclusion Patients with large atherosclerotic cerebral infarction are treated with a combination of argatroban and clopidogrel,which can improve neurological defi cits and serum infl ammatory factor levels,and improve the treatment eff ect and the life ability of patients.

关 键 词：大动脉粥样硬化性脑梗死 阿加曲班 氯吡格雷 临床疗效 血清炎性因子 

分 类 号：R743.3[医药卫生—神经病学与精神病学]