纯净水和碱性天然矿泉水对维甲酸诱导的大鼠骨质疏松影响的比较  

A comparative study of the effects of pure water and natural alkaline mineral water on the retinoic acid-induced osteoporosis in rats

作　　者：周洁心 王志媛 蔡圣宝[1] ZHOU Jie-xin;WANG Zhi-yuan;CAI Sheng-bao(Faculty of Agriculture and Food,Kunming University of Science and Technology,Kunming 650500,China;Yunnan Tianwaitian Natural Beverage Co.,Ltd.Kunming 650500,China)

机构地区：[1]昆明理工大学农业与食品学院,云南昆明650500 [2]云南天外天天然饮料有限责任公司,云南昆明650500

出　　处：《云南民族大学学报（自然科学版）》2020年第6期560-564,共5页Journal of Yunnan Minzu University:Natural Sciences Edition

基　　金：北京市重点实验室开放课题。

摘　　要：通过对大鼠的体重、脏器指数、血液指标、骨头参数及组织形态学的分析,比较纯净水和碱性天然矿泉水对维甲酸引起的大鼠骨质疏松症的影响.结果表明:纯净水和碱性天然矿泉水对大鼠的体重和脏器指数没有显著的影响.碱性天然矿泉水组大鼠的血钙、血磷浓度、ALP以及Ct-BMD、Cancell-BMD、T-BMD、Tb-Ar和Polar moment等骨参数的平均值要稍优于纯净水组,但没有显著的统计学差异(p>0.05).碱性天然矿泉水组的Ct-Th要显著地好于纯净水组(p<0.05),破骨细胞数量明显少于纯净水组(p<0.05).相较于纯净水,碱性天然矿泉水可能对维甲酸诱导的大鼠骨质疏松症症状具有一定的缓解作用.This study aimed to compare the effects of pure water and natural alkaline mineral water on the retinoic acid-induced osteoporosis in rats. The body weight, viscera index, blood index, bone parameters and histomorphology of rats were analyzed. The results showed that pure water and natural alkaline mineral water had no significant effect on their body weight and viscera index. The mean values of serum calcium, serum phosphorus, ALP, Ct-BMD, Cancell-BMD, T-BMD, Tb-Ar and polar moment in the natural-alkaline-mineral-water group were better than those in the pure-water group, but there was no significantly statistical difference(p>0.05). The Ct-Th of the natural-alkaline-mineral-water group was significantly better than that of the pure-water group, and the number of osteoclasts in the natural-alkaline-mineral-water group was significantly lower than that in the pure-water group(p<0.05). This study indicates that when compared with pure water, natural alkaline mineral water may relieve some symptoms of osteoporosis induced by retinoic acid in rats.

关 键 词：骨质疏松 维甲酸 碱性天然矿泉水 破骨细胞 骨密度 

分 类 号：R123[医药卫生—环境卫生学] R285.5[医药卫生—公共卫生与预防医学]