Fascin-1蛋白在结直肠腺瘤中的表达及其临床病理意义  

Expression of Fascin-1 protein in colorectal adenoma and its clinicopathological significance

作　　者：邵俊康 王艳 邵峰 王倩 黄必飞 王超群 Shao Junkang;Wang Yan;Shao Feng;Wang Qian;Huang Bifei;Wang Chaoqun(Department of Pathology,Dongyang People's Hospital(Dongyang Hospital,Wenzhou Medical University),Dongyang 322100,China;Department of Medical Oncology,Dongyang People's Hospital(Dongyang Hospital,Wenzhou Medical University),Dongyang 322100,China;Department of Anus and Intestine Surgery,Dongyang People's Hospital(Dongyang Hospital,Wenzhou Medical University),Dongyang 322100,China)

机构地区：[1]东阳市人民医院,温州医科大学附属东阳医院病理科,322100 [2]东阳市人民医院温州医科大学附属东阳医院肿瘤内科,322100 [3]东阳市人民医院温州医科大学附属东阳医院肛肠外科,322100

出　　处：《国际医药卫生导报》2020年第24期3809-3812,共4页International Medicine and Health Guidance News

摘　　要：目的探讨Fascin-1蛋白在结直肠腺瘤中的表达及其临床病理意义。方法收集2008年1月至2015年12月本院病理科结直肠腺瘤石蜡标本73例和同时切除的正常结直肠组织石蜡标本28例。采用免疫组织化学EnVision二步法检测结直肠腺瘤和正常结直肠组织中Fascin-1蛋白的表达,并分析其表达与结直肠腺瘤患者各项临床病理特征的关系。结果正常结直肠组织和结直肠腺瘤组织中Fascin-1蛋白表达阳性率分别为0.0%(0/28)、53.4%(39/73),差异有统计学意义(P<0.05);Fascin-1蛋白在组织学高级别腺瘤中的阳性率为65.9%(27/41),显著高于低级别腺瘤37.5%(12/32),差异有统计学意义(P<0.05);在绒毛状腺瘤中Fascin-1蛋白阳性率为85.7%(12/14),显著高于管状腺瘤42.9%(9/21)及管状绒毛状腺瘤47.4%(18/38),差异有统计学意义(P<0.05);在不同性别、年龄、部位的结直肠腺瘤中Fascin-1蛋白阳性率比较,差异均无统计学意义(均P>0.05)。结论Fascin-1可能在结直肠腺瘤发生、发展过程中起了重要作用。Objective To investigate the expression of Fascin-1(FSCN1)protein in colorectal adenoma and its clinicopathological significance.Methods The expression of Fascin-1 protein in 28 normal colorectal tissues and 73 colorectal adenomas tissues diagnosed at our hospital from January,2008 to December,2015 was detected by the immunohistochemical EnVision method.The relationship between the expression of Fascin-1 protein and clinicopathological features of colorectal adenoma patients was analyzed.Results The positive rates of Fascin-1 protein in the normal colorectal tissue and the colorectal adenoma were 0.0%(0/28)and 53.4%(39/73),respectively,with a statistical difference(P<0.05).The positive rate of Fascin-1 protein in the histological high-grade adenomas was 65.9%(27/41),which was significantly higher than that in low-grade adenomas(37.5%,12/32)(P<0.05).The positive rate of Fascin-1 protein in the villous adenoma was 85.7%(12/14),which was significantly higher than that in the tubular adenoma(42.9%,9/21)and that in the tubular villous adenoma(47.4%,18/38)(P<0.05).There were no statistical differences in the positive rates of Fascin-1 protein in the colorectal adenomas between different genders,ages,and locations(all P>0.05).Conclusions Fascin-1 may play an important role in the occurrence and development of colorectal adenoma.

关 键 词：FASCIN-1 结直肠腺瘤 免疫组织化学 

分 类 号：R735.34[医药卫生—肿瘤]