MicroRNA在缺氧缺血性脑病调控机制中的研究进展  

Research progress of microRNA in the regulatory mechanism of hypoxic-ischemic encephalopathy

作　　者：刘春阳 曾会勤 刘敏 哈什姆 刘泽源 韩语纯 徐辉[1] LIU Chun-yang;ZENG Hui-qin;LIU Min;Hisham Alward;LIU Ze-yuan;HAN Yu-chun;XU Hui(School of Basic Medical Science, Jiamusi University, Jiamusi 154007, China;The First Affiliated Hospital of Xiamen University, Xiamen 361003, China;Beijing Friendship Hospital, Capital Medical University, Beijing100000, China;The First Hospital of Jilin University, Changchun 130000, China)

机构地区：[1]佳木斯大学基础医学院,黑龙江佳木斯154007 [2]厦门大学附属第一医院,福建厦门361003 [3]首都医科大学附属北京友谊医院,北京100000 [4]吉林大学白求恩第一医院,吉林长春130000

出　　处：《海南医学院学报》2020年第24期1907-1913,共7页Journal of Hainan Medical University

基　　金：国家自然科学基金(30671803,81273174);国家级大学生创新创业项目(201810222013)。

摘　　要：微小RNA(microRNA)在神经系统疾病分子调控中起关键作用,而miRNA的分子机制与缺血缺氧性脑病的发生与发展密切相关。近来有研究报道,多种miRNA分子可通过与靶mRNA的完全互补结合或不完全互补结合来抑制靶mRNA,甚至降解靶mRNA。因此,miRNA对缺氧缺血性脑病相关mRNA的研究颇具重要意义。本文主要从miRNA的分子机制、功能及调控对缺血缺氧性脑病的影响等方面进行简要综述。MicroRNA(miRNA)plays a key role in the molecular regulation of neurological diseases,and the molecular mechanism of miRNA is closely related to the occurrence and development of Hypoxic-Ischemic Encephalopathy.Recently,it has been reported that various miRNA molecules can inhibit target mRNA and even degrade target mRNA by changing the complete complementary or incomplete complementary binding to the target mRNA.Therefore,miRNA is of great significance for the study of mRNA related to Hypoxic-Ischemic Encephalopathy.This article briefly reviews the molecular mechanisms,functions and regulation of miRNAs on Hypoxic-Ischemic Encephalopathy.

关 键 词：微小RNA 缺氧缺血性脑病 新生儿 调控分子机制 生物信息学 

分 类 号：R742[医药卫生—神经病学与精神病学]