维生素D及其受体介导microRNA的抗癌作用机制研究进展  

Research progress on the anticancer mechanism of microRNAmediated by vitamin D and its receptor

作　　者：张强 郭苗苗[1] 张涛[1] 路宏朝[1] 王珊珊 王令[1] ZHANG Qiang;GUO Miao-miao;ZHANG Tao;LU Hong-zhao;WANG Shan-shan;WANG Ling(School of Bioscience and Engineering,Shaanxi University of Technology,Hanzhong 723000,China)

机构地区：[1]陕西理工大学生物科学与工程学院,陕西汉中723000

出　　处：《陕西理工大学学报（自然科学版）》2020年第6期60-68,共9页Journal of Shaanxi University of Technology:Natural Science Edition

基　　金：陕西省教育厅专项科研计划项目(20JK0570);陕西省教育厅专项科研计划项目(20JK0574)。

摘　　要：维生素D受体(VDR)作为转录调控因子与活性维生素D(VD)结合形成VD/VDR复合物调控靶基因的转录。跟踪近年VD/VDR调控microRNA的表达,发挥抗肿瘤作用相关研究报道,总结了VD抗肿瘤的主要途径;分析不同癌细胞内VD/VDR调控特异microRNA表达差异,实现了抗肿瘤作用的信号通路;揭示了VD/VDR介导microRNA促进癌细胞凋亡、抑制癌细胞增殖和转移的抗癌分子机制。可以启发研究者开展相关研究,为研发抗肿瘤的VD类药物提供参考。Vitamin D Receptor(VDR),as a regulatory factor of transcription,binds with active vita-min D(VD)to form VD/VDR complex to regulate the transcription of target genes.The study has reviewed the recent studies of vitamin D or the VD receptor(VD/VDR)regulating the expression of microRNAs,and summarized VD/VDR anti-tumor pathways.It has also analyzed specific microRNAs expression in different cancer cells,and realized the signal pathways of anti-tumor effects.The paper has revealed the molecular mechanism of VD anti-cancer that is VD/VDR mediates microRNAs to promote cancer cell apoptosis and inhibit cancer cell proliferation and metastasis.In summary,this review aims to inspire researchers to carry out related research and provide references for the development of VD anti-tumor drugs.

关 键 词：维生素D 维生素D受体 MICRORNA 肿瘤细胞 转录调控 

分 类 号：R730.5[医药卫生—肿瘤]