消化系统恶性肿瘤患者营养风险的相关危险因素  

Related risk factors of nutritional risk in patients with digestive system malignant tumor

作　　者：张雨 张敏[1] 姬颖华[1] 李伟伟[1] 杨庆辉[1] 张正 路平[1] ZHANG Yu;ZHANG Min;JI Yinghua;LI Weiwei;YANG Qinghui;ZHANG Zheng;LU Ping(Department of Oncology,the First Affiliated Hospital of Xinxiang Medical University,Xinxiang 453100,Henan Province,China)

机构地区：[1]新乡医学院第一附属医院肿瘤科,河南新乡453100

出　　处：《新乡医学院学报》2020年第11期1049-1052,共4页Journal of Xinxiang Medical University

基　　金：河南省医学科技攻关计划项目(编号:201702124)。

摘　　要：目的探讨消化系统恶性肿瘤患者发生营养风险的相关危险因素。方法选择新乡医学院第一附属医院肿瘤科2017年9月至2019年11月收治的101例消化系统恶性肿瘤患者为研究对象,根据营养风险筛查2002评分量表,将患者分为无营养风险组(n=59)和有营养风险组(n=42)。比较2组患者的生存质量及炎症指标的变化;采用logistic回归分析筛选消化系统恶性肿瘤患者发生营养风险的危险因素,并制作受试者工作特征曲线判断独立危险因素对于消化系统恶性肿瘤患者发生营养风险的检验效能。结果有营养风险组患者的年龄大于无营养风险组(P<0.05),曾接受放射治疗的比例高于无营养风险组(P<0.05),体质量指数(BMI)、躯体功能、角色功能、社会功能、总体生活质量、卡氏功能状态(KPS)评分低于无营养风险组(P<0.05);2组患者的性别、肿瘤部位、病理类型、临床分期、曾接受化学治疗患者的比例比较差异均无统计学意义(P>0.05)。有营养风险组患者中性粒细胞计数、中性粒细胞百分比、血小板淋巴细胞比(PLR)均高于无营养风险组患者(P<0.05);2组患者白细胞计数比较差异无统计学意义(P>0.05)。躯体功能、BMI、KPS评分、PLR是消化系统恶性肿瘤患者发生营养风险的独立危险因素(P<0.05),且对判断消化系统恶性肿瘤患者存在营养风险均具有较好的检验效能。结论存在营养风险的消化系统恶性肿瘤患者生存质量明显下降,临床炎症指标明显增高,躯体功能、BMI、KPS评分、PLR可作为判断消化系统恶性肿瘤患者发生营养风险的独立危险因素。Objective To explore the related risk factors of nutritional risk in patients with digestive system malignant tumor.Methods One hundred and one patients with digestive system malignant tumor in the Department of Oncology,the First Affiliated Hospital of Xinxiang Medical College from September 2017 to November 2019 were selected as the research objects.And they were divided into non-nutritional risk group(n=59)and nutritional risk group(n=42)according to the nutrition risk screening 2002 scores.The quality of life and inflammatory indexes were compared between the two groups.The risk factors of nutritional risk of patients with digestive system malignant tumer were screened by logistic regression,and the receiver operating characteristic curve was made to judge the test efficacy of all risk factors.Results The age of patients in the nutritional risk group was larger than that in the non-nutritional risk group(P<0.05);the proportion of patients who received radiotherapy in the nutritional risk group was higher than that in the non-nutritional risk group(P<0.05);the body mass index(BMI),body function,role function,social function,overall quality of life,Karnofsky performance status(KPS)scores of patients in the nutritional risk group were lower than those in the non-nutritional risk group(P<0.05);there were no significant difference in the sex,tumor location,pathological type,clinical stage and the proportion of patients who had received chemotherapy between the two groups(P>0.05).The neutrophil count,neutrophil percentage and platelet-to-lymphocyte ratio(PLR)of patients in the nutritional risk group were higher than those in the non-nutritional risk group(P<0.05);there was no significant difference in white blood cell count between the two groups(P>0.05).The body function,BMI,KPS scores,and PLR were the independent risk factors of nutritional risk in patients with digestive system malignant tumer(P<0.05);and all of them have good test efficiency.Conclusion The quality of life of patients with digestive system malig

关 键 词：消化系统恶性肿瘤 营养风险 生存质量 炎症反应 危险因素 

分 类 号：R735[医药卫生—肿瘤]