小胶质细胞活化对脑出血后继发性脑损伤作用的研究进展  

Advances in the effects of microglia activation on secondary brain injury after intracerebral hemorrhage

作　　者：武翠梅 王改青[2] 要振佳 柏琴琴 刘丽荣 Wu Cuimei;Wang Gaiqing;Yao Zhenjia;Bai Qinqin;Liu Lirong(Second Medical College of Shanxi Medical University,Taiyuan 030000,China;不详)

机构地区：[1]山西医科大学第二临床医学院,太原030000 [2]山西医科大学第二医院神经内科

出　　处：《中国脑血管病杂志》2020年第12期761-765,共5页Chinese Journal of Cerebrovascular Diseases

基　　金：国家自然科学基金(81771294)。

摘　　要：小胶质细胞是参与防御脑损伤的主要免疫细胞。脑出血后,小胶质细胞被激活,吞噬受损神经细胞和红细胞,并分泌大量炎性因子和抗炎因子,在脑出血后继发性脑损伤中发挥神经毒性及损伤修复双重作用。该文就脑出血后小胶质细胞活化及其作用展开综述,探讨小胶质细胞在脑出血后继发性脑损伤中的作用。Microglia cells are the main immune cells involved in the defense against brain damage.After intracerebral hemorrhage,microglia cells are activated to engulf damaged nerve cells and red blood cells,and secrete a large number of inflammatory factors and anti-inflammatory factors,which play a dual role of neurotoxicity and injury repair in secondary brain injury after intracerebral hemorrhage.This article reviews the activation of microglia after cerebral hemorrhage and its mechanism of action,in order to investigate the role of microglia cells in the secondary brain injury after intracerebral hemorrhage.

关 键 词：小神经胶质细胞 脑出血 脑损伤 慢性 综述 

分 类 号：R743.34[医药卫生—神经病学与精神病学]