Noninvasive in vivo cell tracking using molecular imaging:A useful tool for developing mesenchymal stem cell-based cancer treatment  

作　　者：Ramya Lakshmi Rajendran Manasi Pandurang Jogalekar Prakash Gangadaran Byeong-Cheol Ahn 

机构地区：[1]Department of Nuclear Medicine,Kyungpook National University,Daegu 41944,South Korea [2]Brigham and Women’s Hospital,Harvard Medical School,Boston,MA 02115,United States [3]Department of Nuclear Medicine,School of Medicine,Kyungpook National University,Daegu 41944,South Korea [4]BK21 Plus KNU Biomedical Convergence Program,Department of Biomedical Science,School of Medicine,Kyungpook National University,Daegu 41944,South Korea [5]Department of Nuclear Medicine,School of Medicine,Kyungpook National University,Kyungpook National University Hospital,Daegu 41944,South Korea

出　　处：《World Journal of Stem Cells》2020年第12期1492-1510,共19页世界干细胞杂志（英文版）（电子版）

基　　金：Supported by Basic Science Research Program via the National Research Foundation of Korea(NRF)funded by the Ministry of Education,Republic of South Korea,No.NRF-2019R1I1A1A01061296 and No.NRF-2019R1I1A3A01063308.

摘　　要：Mounting evidence has emphasized the potential of cell therapies in treating various diseases by restoring damaged tissues or replacing defective cells in the body.Cell therapies have become a strong therapeutic modality by applying noninvasive in vivo molecular imaging for examining complex cellular processes,understanding pathophysiological mechanisms of diseases,and evaluating the kinetics/dynamics of cell therapies.In particular,mesenchymal stem cells(MSCs)have shown promise in recent years as drug carriers for cancer treatment.They can also be labeled with different probes and tracked in vivo to assess the in vivo effect of administered cells,and to optimize therapy.The exact role of MSCs in oncologic diseases is not clear as MSCs have been shown to be involved in tumor progression and inhibition,and the exact interactions between MSCs and specific cancer microenvironments are not clear.In this review,a multitude of labeling approaches,imaging modalities,and the merits/demerits of each strategy are outlined.In addition,specific examples of the use of MSCs and in vivo imaging in cancer therapy are provided.Finally,present limitations and future outlooks in terms of the translation of different imaging approaches in clinics are discussed.

关 键 词：Cell therapy Mesenchymal stem cells In vivo molecular imaging Drug delivery Superparamagnetic iron oxide 

分 类 号：R730.5[医药卫生—肿瘤]