Infliximab is effective in the treatment of ulcerative colitis with dermatomyositis:A case report  

作　　者：Bin-Bin Huang Li-Chun Han Geng-Feng Liu Xiao-Dan Lv Guang-Li Gu Shi-Quan Li Lan Chen Hui-Qin Wang Ling-Ling Zhan Xiao-Ping Lv 

机构地区：[1]Department of Gastroenterology,The First Affiliated Hospital of Guangxi Medical University,Nanning 530021,Guangxi Zhuang Autonomous Region,China [2]Department of Clinical Laboratory,The First Affiliated Hospital of Guangxi Medical University,Nanning 530021,Guangxi Zhuang Autonomous Region,China

出　　处：《World Journal of Gastroenterology》2020年第46期7425-7435,共11页世界胃肠病学杂志（英文版）

基　　金：the National Natural Science Foundation of China,No.81860104 and 81460114;the Natural Science Foundation of Guangxi Zhuang Autonomous Region,No.2017GXNSFAA198299;the Development and Application of Medical and Health Appropriate Technology Project in Guangxi Zhuang Autonomous Region,No.S2018049;the Youth Science Foundation of Guangxi Medical University,No.GXMUYSF201913 and GXMUYSF201908;the Self-financing Project of Health Commission of Guangxi Zhuang Autonomous Region,No.Z20200398。

摘　　要：BACKGROUND Joint,skin,oral cavity,and eye lesions are the most common extraintestinal manifestations of ulcerative colitis that can occur before or after its onset.The cases of ulcerative colitis with dermatomyositis(DM)are rare.In this study,we report a rare case of ulcerative colitis with DM that was effectively treated with infliximab.CASE SUMMARY The patient was a 57-year-old female with a 2-year history of DM.The patient was admitted to hospital with abdominal pain,diarrhea,and blood in stool lasting for more than 2 mo.Colonoscopy revealed multiple erosions and ulcers in the entire colon and rectum.Pathological sections showed chronic inflammatory cell infiltration,especially neutrophil infiltration,in the colonic mucosa;therefore,the patient was diagnosed with ulcerative colitis.Preparations of 5-aminosalicylic acid was added to her treatment based on the original treatment for DM,but its effect was unsatisfactory.The patient’s discomfort was relieved after infliximab treatment.CONCLUSION Infliximab can improve DM in the treatment of ulcerative colitis.Specialists need to raise awareness about patients with inflammatory bowel disease who have rare extraintestinal manifestations.

关 键 词：Ulcerative colitis DERMATOMYOSITIS Extraintestinal manifestation INFLIXIMAB MESALAZINE Case report 

分 类 号：R574.62[医药卫生—消化系统] R593.26[医药卫生—内科学]