Three-year follow-up of Coats disease treated with conbercept and 532-nm laser photocoagulation  

作　　者：Li Jiang Bo Qin Xiao-Ling Luo He Cao Ting-Ming Deng Ming-Ming Yang Ting Meng Hui-Qin Yang 

机构地区：[1]Department of Ophthalmology,Shenzhen People’s Hospital,Second Clinical Medical College of Jinan University,Shenzhen 518020,Guangdong Province,China [2]Department of Ophthalmology,Shenzhen Aier Eye Hospital Affiliated to Jinan University,Shenzhen 518032,Guangdong Province,China

出　　处：《World Journal of Clinical Cases》2020年第24期6243-6251,共9页世界临床病例杂志

基　　金：Supported by the Shenzhen Municipal Health and Family Planning System Research Project,No.SZFZ2017085.

摘　　要：BACKGROUND Coats disease is an idiopathic exudative outer retinopathy caused by abnormalretinal vascular development.AIM To evaluate the long-term outcomes of intravitreal conbercept injection with laserphotocoagulation as a treatment for Coats disease in adults.METHODS This retrospective case series study included patients diagnosed with Coatsdisease and treated with intravitreal conbercept injection and 532-nm laserphotocoagulation at the Ophthalmology Department of Shenzhen People’sHospital between January 2016 and January 2017. Best-corrected visual acuity(BCVA) measurements, noncontact tonometry, ophthalmoscopy, fundusphotography, fundus fluorescein angiography and optical coherence tomographywere performed before treatment and at 1 wk, 1 mo, 3 mo, 6 mo, 9 mo, 12 mo, 24mo and 36 mo after therapy. Best-corrected visual acuity was measured using theearly treatment of diabetic retinopathy study chart.RESULTS The study included eight eyes of 8 patients (7 men) aged 36.10 ± 6.65 years. Theaverage BCVA of the affected eye before treatment was 51.17 ± 15.15 letters(range, 28–70 letters), and the average central macular thickness was 303.30 ±107.87 μm (range, 221–673 μm). Four eyes were injected once, three were injectedtwice, and one was injected three times. Average follow-up duration was 37.33 ±2.26 mo. Average BCVA of the affected eye was 51.17 ± 15.15 letters before treatment and was increased by 13.50 ± 3.20, 16.25 ± 7.73, 18.25 ± 8.96, 18.03 ± 5.27,18.63 ± 3.35, 19.75 ± 6.96, 18.05 ± 5.36 and 17.88 ± 3.45 letters at 1 wk, 1 mo, 3 mo, 6mo, 9 mo, 12 mo, 24 mo and 36 mo after treatment, respectively (P < 0.01). Thepatients showed varying degrees of subretinal fluid resorption after treatment.None of the patients had serious complications such as increased intraocularpressure, development/progression of cataracts, endophthalmitis or retinaldetachment.CONCLUSION Intravitreal injection of conbercept combined with 532-nm laser photocoagulationmay be a feasible treatment for Coats disease in adul

关 键 词：Coats disease ADULTS Retinal telangiectasis Conbercept Laser therapy Retrospective study 

分 类 号：R779.6[医药卫生—眼科]