清热排脓汤合千金苇茎汤辅助化疗治疗痰瘀互结型肺癌临床研究  

Clinical Study on Qingre Painong Tang and Qianjin Weijing Tang Combined with Chemotherapy for Lung Cancer of Binding of Phlegm and Stasis Type

作　　者：刘东虎 张涛 廖校贤 胡群峰 LIU Donghu;ZHANG Tao;LIAO Xiaoxian;HU Qunfeng

机构地区：[1]广州中医药大学金沙洲医院,广东广州510415

出　　处：《新中医》2020年第22期104-108,共5页New Chinese Medicine

摘　　要：目的:探讨清热排脓汤合千金苇茎汤辅助化疗治疗痰瘀互结型肺癌的临床疗效。方法:将92例痰瘀互结型肺癌患者按随机数字表法分为研究组和对照组各46例。对照组采用紫杉醇与顺铂联合化疗方案治疗,研究组在对照组基础上给予清热排脓汤合千金苇茎汤治疗。观察2组临床疗效,比较治疗前后T淋巴细胞(CD3+、CD8+、CD4+/CD8+)水平、中医证候积分、生活质量(FACT-L)评分、毒副反应发生情况。结果:研究组肿瘤控制率为84.78%,高于对照组65.22%,差异有统计学意义(P<0.05)。治疗前,2组CD3+、CD8+、CD4+/CD8+水平无明显差异(P>0.05)。治疗后,研究组CD3+、CD4+/CD8+水平高于治疗前和对照组,CD8+水平低于治疗前和对照组,差异均有统计学意义(P<0.05)。治疗前,2组中医证候积分比较,差异无统计学意义(P>0.05)。治疗后,2组中医证候积分较治疗前降低,且研究组中医证候积分低于对照组,差异均有统计学意义(P<0.05)。治疗前,2组FACT-L评分比较,差异无统计学意义(P>0.05)。治疗后,2组FACT-L评分较治疗前增高,且研究组FACT-L评分高于对照组,差异均有统计学意义(P<0.05)。研究组血红蛋白减少、白细胞减少、肝肾功能异常、呕吐恶心发生率均低于对照组(P<0.05)。结论:清热排脓汤合千金苇茎汤辅助化疗治疗痰瘀互结型肺癌患者临床疗效确切,可降低中医证候积分,改善免疫功能,提高生活质量,减轻毒副反应。Objective: To discuss the clinical effect of Qingre Painong tang and Qianjin Weijing tang combined with chemotherapy for the lung cancer of binding of phlegm and stasis type. Methods:A total of 92 cases of patients with the lung cancer of binding of phlegm and stasis type were divided into the study group and the control group according to the random number table method,46 cases in each group. The control group was given combined chemotherapy regimen with paclitaxel and cisplatin, and the study group was additionally given Qingre Painong tang and Qianjin Weijing tang based on the treatment of the control group. The clinical effect in the two groups was observed. Before and after treatment,the levels of T lymphocytes,namely,CD3^+,CD8^+and CD4^+/CD8^+,Chinese medicine syndrome scores,scores of Functional Assessment of Cancer Treatment-Lung(FACT-L), and the incidence of toxic side effects were compared between the two groups.Results: The tumor control rate was 84.78% in the study group, higher than that of 65.22% in the control group, the difference being significant(P<0.05). Before treatment,when compared the levels of CD3^+,CD8^+and CD4^+/CD8^+between the two groups,there was no significant difference(P>0.05). After treatment,the levels of CD3^+and CD4^+/CD8^+in the study group were higher than those before treatment and in the control group,and the level of CD8^+was lower than that before treatment and that in the control group,differences being significant(P<0.05). Before treatment,when compared Chinese medicine syndrome scores between the two groups,there was no significance in the difference(P>0.05). After treatment,Chinese medicine syndrome scores in the two groups were decreased when compared with those before treatment,and the scores in the study group were lower than those in the control group, differences being significant(P<0.05). Before treatment,when compared scores of FACT-L between the two groups,there was no significance in the difference(P>0.05).After treatment,scores of FACT-L in the two groups we

关 键 词：肺癌 痰瘀互结型 清热排脓汤 千金苇茎汤 化疗 中医证候积分 免疫功能 

分 类 号：R734.2[医药卫生—肿瘤]