Hepatitis E virus re-infection accelerates hepatocellular carcinoma development and relapse in a patient with liver cirrhosis:A case report and review of literature  

作　　者：Xiao-Na Lin Qiu-Xiong Lin Shu-Mei Li Ke-Ping Xie Jun Hou Ren Chen 

机构地区：[1]The Laboratory of Computational Medicine and Systems Biology,School of Medicine,South China University of Technology,Guangzhou 510006,Guangdong Province,China [2]Department of Infectious Disease,Guangdong General Hospital&Guangdong Academy of Medical Sciences,Guangzhou 510080,Guangdong Province,China [3]School of Medicine,South China University of Technology,Guangzhou 510000,Guangdong Province,China

出　　处：《World Journal of Hepatology》2020年第12期1358-1366,共9页世界肝病学杂志（英文版）（电子版）

摘　　要：BACKGROUND Hepatitis E virus(HEV)superinfection is a suspected promoting factor for hepatocellular carcinoma(HCC)in patients with chronic hepatitis and cirrhosis.However,to date,very few cases of HEV-related HCC have been reported.Nevertheless,the role of HEV re-infection in cirrhotic liver without other chronic hepatitis infections has rarely been explored.CASE SUMMARY A 53-year-old male farmer was diagnosed with liver cirrhosis and splenomegaly in August 2016,accompanied with negative HEV-IgM and positive HEV-IgG.No evidence of hepatitis B virus or hepatitis C virus infection was found.Since then the patient was evaluated for liver function and viral parameters every 3 mo.In June 2017,the patient presented severe fatigue with whole body itching and was diagnosed with HCC.Afterwards this patient experienced quick HCC development,progression,relapse,and metastasis in the following 8 mo,and presented persistent dual positivity of HEV-IgM and HEV-IgG.This patient had a long history of smoking and alcohol consumption.CONCLUSION This unique case invokes the importance of HEV surveillance and treatment among cirrhotic patients,HCC cases,and blood donors.

关 键 词：Hepatitis E virus RE-INFECTION Hepatocellular carcinoma CIRRHOSIS Case report 

分 类 号：R512.6[医药卫生—内科学] R575.2[医药卫生—临床医学] R735.7