Stem cell quiescence and its clinical relevance  

作　　者：Meng Luo Jin-Fan Li Qi Yang Kun Zhang Zhan-Wei Wang Shu Zheng Jiao-Jiao Zhou 

机构地区：[1]Department of Breast Surgery,The Second Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310009,Zhejiang Province,China [2]Cancer Institute,Key Laboratory of Cancer Prevention and Intervention,China National Ministry of Education,Zhejiang University School of Medicine,Hangzhou 310009,Zhejiang Province,China [3]Department of Pathology,The Second Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310009,Zhejiang Province,China [4]Department of Breast Surgery,Huzhou Central Hospital,Affiliated Central Hospital Huzhou University,Huzhou 313003,Zhejiang Province,China

出　　处：《World Journal of Stem Cells》2020年第11期1307-1326,共20页世界干细胞杂志（英文版）（电子版）

摘　　要：Quiescent state has been observed in stem cells(SCs),including in adult SCs and in cancer SCs(CSCs).Quiescent status of SCs contributes to SC self-renewal and conduces to averting SC death from harsh external stimuli.In this review,we provide an overview of intrinsic mechanisms and extrinsic factors that regulate adult SC quiescence.The intrinsic mechanisms discussed here include the cell cycle,mitogenic signaling,Notch signaling,epigenetic modification,and metabolism and transcriptional regulation,while the extrinsic factors summarized here include microenvironment cells,extracellular factors,and immune response and inflammation in microenvironment.Quiescent state of CSCs has been known to contribute immensely to therapeutic resistance in multiple cancers.The characteristics and the regulation mechanisms of quiescent CSCs are discussed in detail.Importantly,we also outline the recent advances and controversies in therapeutic strategies targeting CSC quiescence.

关 键 词：Stem cell Cancer stem cell QUIESCENCE Targeting quiescence 

分 类 号：R329.2[医药卫生—人体解剖和组织胚胎学]