Gadolinium Oxide Nanocrystals Sensitize Non-small Cell Lung Cancer Cells to X-ray Irradiation via Promoting Cytostatic Autophagy  

氧化钆纳晶通过促进细胞死亡自噬增强X射线对非小细胞肺癌细胞损伤

作　　者：Chen Weiqiang Li Feifei Liu Yan Jin Xiaodong Li Qiang 

机构地区：[1]不详

出　　处：《IMP & HIRFL Annual Report》2018年第1期143-143,共1页中国科学院近代物理研究所和兰州重离子研究装置年报（英文版）

摘　　要：Gadolinium-based nanoparticles(GdNPs)have been used as theranostic sensitizers in clinical radiotherapy study[1],but the biomechanisms underlying the radiosensitizing effect of GdNPs are still undisclosed.In this study,ultra-small gadolinium oxide nanocrystals(GON)was employed to investigate their radiosensitizing effect and biological mechanisms in non-small cell lung cancer(NSCLC)cells under X-ray irradiation.Using a polyol method,GON was synthesized[2].In the previous study,GON caused hydroxyl radical production and oxidative stress in a dose-and concentration-dependent manner in NSCLC cells after X-ray irradiation.The radiation enhancements of GON reached 19.3%26.3%for the NSCLC cells under investigation at 10%survival level compared with irradiation alone.

关 键 词：LUNG NSCLC LUNG 

分 类 号：R73[医药卫生—肿瘤]