卵巢癌肿瘤微环境中树突状细胞功能的研究进展  

Progress on Dendritic Cell Function in Ovarian Cancer Tumor Microenvironment

作　　者：高云鸽 钱罗蒙 汪梦馨 徐盈 陈必良 GAO Yun-ge;QIAN Luo-meng;WANG Meng-xin;XU Ying;CHEN Bi-liang(Xijing Hospital,Fourth Military Medical University,Xi'an 710032,China)

机构地区：[1]空军军医大学第一附属医院西京医院,陕西西安710032

出　　处：《肿瘤学杂志》2020年第11期953-956,共4页Journal of Chinese Oncology

基　　金：空军军医大学第一附属医院学科助推计划(XJZT18MJ53)。

摘　　要：树突状细胞是参与抗肿瘤免疫反应的始动细胞,在肿瘤的进展中扮演着不可或缺的角色,而卵巢癌患者体内树突状细胞的功能发生了诸多变化。多项研究表明,肿瘤微环境中存在免疫抑制介质,能够通过多种途径引起严重的树突状细胞功能障碍,影响着卵巢癌的进展与预后。全文对卵巢癌肿瘤微环境中树突状细胞的功能和作用作一综述,以期为改善卵巢癌的免疫治疗寻找新思路。Dendritic cells are the initiating cells involved in the anti-tumor immune response,and play indispensable roles in the progression of tumors. There are many changes in dendritic cell functions in patients with ovarian cancer. A great deal of studies have shown that the presence of immunosuppressive mediators in the tumor microenvironment may cause severe dysfunction of dendritic cells through multiple pathways,and affect the progression and prognosis of ovarian cancer. This article reviews the functions and effects of dendritic cells in the ovarian cancer tumor microenvironment,which would provide new ideas for improving the immunotherapy of ovarian cancer.

关 键 词：卵巢癌 树突状细胞 肿瘤微环境 免疫逃逸 

分 类 号：R737.31[医药卫生—肿瘤]