New lobane-type diterpenoids from the Xisha soft coral Sinularia polydactyla  

作　　者：YE Fei CHEN Zi-Hui GU Yu-Cheng GUO Yue-Wei LI Xu-Wen 

机构地区：[1]State Key Laboratory of Drug Research,Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai 201203.China [2]Open Studio for Druggability Research of Marine Natural Products,Qingdao National Laboratory for Marine Science and Technology,Qingdao 266237.China [3]University of Chinese Academy of Sciences,Beijing 100049,China [4]Syngenta,Jealott's Hill International Research Centre,Bracknell,Berkshire RG426EY,United Kingdom

出　　处：《Chinese Journal of Natural Medicines》2020年第11期839-843,共5页中国天然药物（英文版）

基　　金：supported by the National Key Research and Development Program of China (No. 2018YFC-0310903);the Natural Science Foundation of China (Nos. 81991521;21672230;and 81520108028);the NSFC/CNRS Joint Project (No.81811530284);the SKLDR/SIMM Project (No. SIMM1903ZZ-04);Shanghai Rising-Star Program (No. 20QA1411100);SA-SIBS Scholarship Program;Syngenta-SIMM-Ph D Studentship Project。

摘　　要：Lobane-type diterpenoids are not frequently discovered from marine soft corals. In this paper, three new lobane type diterpenes, 13-methoxyloba-8,10,15(16),17(18)-tetraene(1), 8,10,13(15)Z,16 E-lobatetraene(2) and 19-hydroxy-lobatetraene(3), and a new natural compound, 17,18-epoxyloba-16-acetoxy-8,10,13(15)-trien(4), co-occurring with a known related diterpenoid, 18-methoxyloba-8,10,13(15),16(17)-tetraene(5), were isolated from the South China Sea soft coral Sinularia polydactyla. The structures of new compounds were determined by extensive spectroscopic analysis and by comparison with those reported in the literature. In bioassay, all the isolates were inactive on antibacterial, PTP1 B inhibitory, and immunological activities. This study increased the chemical diversity of marine diterpenoids.

关 键 词：Soft coral Sinularia polydactyla Lobane DITERPENES 

分 类 号：R284.1[医药卫生—中药学]