Penicacids E-G, three new mycophenolic acid derivatives from the marine-derived fungus Penicillium parvum HDN17-478  

作　　者：CHEN Xiao-Hui ZHOU Guo-Liang SUN Chun-Xiao ZHANG Xiao-min ZHANG Guo-Jian ZHU Tian-Jiao LI Jing CHE Qian LI De-Hai 

机构地区：[1]Key Laboratory of Marine Drugs,Chinese Ministry of Education,School of Medicine and Pharmacy,Ocean University of China,Qingdao 266003,China [2]Laboratory.for Marine Drugs and Bioproducts of Qingdao Pilot National Laboratory for Marine Science and Technology,Qing-dao,266237,China

出　　处：《Chinese Journal of Natural Medicines》2020年第11期850-854,共5页中国天然药物（英文版）

基　　金：supported by the National Key R&D Program of China (No. 2018YFC0310800);the National Science and Technology Major Project for Significant New Drugs Development (No. 2018ZX09735004);the Marine S&T Fund of Shandong Province for Pilot National Laboratory for Marine Science and Technology (Qingdao)(Nos. 2018SDKJ0401-2 and 2016ASKJ05-04);the NSFC-Shandong Joint Fund (No. U1906212);the Fundamental Research Funds for the Central Universities (No. 201941001);the Taishan Scholar Youth Expert Program in Shandong Province (No. tsqn201812021)。

摘　　要：Three new mycophenolic acid derivatives, penicacids E-G(1-3), together with three known analogues, mycophenolic acid(4), 4′-hydroxy-mycophenolic acid(5) and mycophenolic methyl ester(6), were isolated from a marine-derived fungus Penicillium parvum HDN17-478 from a South China Sea marine sediment sample. The structures of compounds 1-3 were elucidated by HRMS, NMR, and Mosher’s method. Among them, compounds 1 and 2 were the first examples of mycophenolic acid analogs with a double bond at C-3′/C-4′ position. The cytotoxicity of 1-6 was evaluated against the HCT-116, BEL-7402, MGC-803, SH-SY5 Y, HO-8910 and HL-60 cell lines, and compounds 4 and 6 showed potent cytotoxicity with IC50 values ranging from 1.69 to 12.98 μmol·L–1.

关 键 词：Mycophenolic acid derivatives Marine-derived fungus Penicillium parvum CYTOTOXICITY 

分 类 号：R284.1[医药卫生—中药学]