内镜窄带成像技术联合放大内镜诊断胃癌准确性的Meta分析  

Diagnostic accuracy of magnifying endoscopy with narrow-band imaging in gastric cancer:a Meta-analysis

作　　者：唐榛 杨亚玲 文黎明 Zhen Tang;Ya-ling Yang;Li-ming Wen(Clinical Medical College,Southwest Medical University,Luzhou,Sichuan 646000,China;Department of Gastroenterology,Sichuan Miangyang 404 Hospital,Miangyang,Sichuan 621000,China)

机构地区：[1]西南医科大学临床医学院,四川泸州646000 [2]四川绵阳四〇四医院消化中心,四川绵阳621000

出　　处：《中国内镜杂志》2020年第12期8-17,共10页China Journal of Endoscopy

基　　金：2020年四川省卫生健康委员会科研课题(No:20PJ269)。

摘　　要：目的探讨放大内镜联合窄带成像技术(ME-NBI)对胃癌的诊断价值。方法全面检索Web of Science、Cochrane Library、PubMed、万方数据库、中国知网和维普中文数据库的相关文献,年限为建库至2019年12月,利用Meta-Disc 1.4和Stata 15.0软件进行Meta分析。结果最终纳入34篇文献,包括7255例胃癌患者和7711处病灶。Meta分析结果显示:ME-NBI诊断胃癌准确性的合并灵敏度(SE)为0.87(95%CI:0.85~0.89);特异度(SP)为0.96(95%CI:0.96~0.97);约登指数(YI)为0.83;阳性似然比(LR+)为10.91(95%CI:7.16~16.61);阴性似然比(LR-)为0.15(95%CI:0.11~0.20);诊断优势比(DOR)为82.61(95%CI:46.64~146.31);综合受试者工作特征曲线(SROC)下面积(AUC)为0.95(95%CI:0.93~0.97)。结论ME-NBI对胃癌有较高的诊断价值,为胃癌诊断的重要手段,可指导临床工作。Objective To explore the diagnostic value of magnifying endoscopy with narrow-band imaging(ME-NBI)in gastric cancer.Methods We searched relevant literatures of Web of Science,Cochrane Library,PubMed,WanFang databases,CNKI and VIP databases comprehensively(up to December 2019).Meta-Disc 1.4 software and Stata 15.0 software were used for meta analysis.Results 34 studies with a total of 7255 gastric cancer patients and 7711 lesions were included in the present analysis.Pooled sensitivity of ME-NBI to diagnose gastric cancer is 0.87(95%CI:0.85~0.89);Pooled specificity of ME-NBI to diagnose gastric cancer is 0.96(95%CI:0.96~0.97);Youden index is 0.83;Positive likelihood ratio(LR+)is 10.91(95%CI:7.16~16.61);Negative likelihood ratio(LR-)is 0.15(95%CI:0.11~0.20);Diagnostic Odds Ratio(DOR)is 82.61(95%CI:46.64~146.31);Area under SROC curve(AUC)is 0.95(95%CI:0.93~0.97).Conclusion ME-NBI has a high diagnostic value for gastric cancer,which can be used as an important measure for diagnosis of gastric cancer and guide clinical work.

关 键 词：胃癌 窄带成像技术 放大内镜 诊断 META分析 

分 类 号：R735.2[医药卫生—肿瘤]