胃癌细胞源性外泌体的腹膜转移机制研究进展  

Progress in the Mechanism of Peritoneal Metastasis of Gastric Cancer Cell-Derived Exosomes

作　　者：林花[1] 王勇[2] 罗倩 路明亮[3] LIN Hua;WANG Yong;LUO Qian;LU Ming-Liang(Laboratory Department,Second Affiliated Hospital of Kunming Medical University,Kunming 650101,China;Pharmacy Department,Second Affiliated Hospital of Kunming Medical University,Kunming 650101,China;Department of Digestive Medicine,Second Affiliated Hospital of Kunming Medical University,Kunming 650101,China)

机构地区：[1]昆明医科大学第二附属医院检验科,云南昆明650101 [2]昆明医科大学第二附属医院药学部,云南昆明650101 [3]昆明医科大学第二附属医院消化内科,云南昆明650101

出　　处：《生物技术通讯》2020年第5期590-593,共4页Letters in Biotechnology

基　　金：云南省卫生和计划生育委员会医学后备人才培养计划(H-2017021)。

摘　　要：胃癌是最常见的癌症之一,其中50%以上的病例发生在东亚地区,在所有恶性肿瘤中死亡率位居第二。由于易于腹膜扩散,转移是胃癌预后不良的主要原因。现有研究认为外泌体参与了胃癌腹膜转移,外泌体可传达潜在的生物信息到附近或远处,并通过损伤腹膜间皮细胞而破坏间皮屏障,进一步引起腹膜纤维化,形成有利于胃癌腹膜转移的转移环境。目前关于外泌体在胃癌腹膜转移中作用的认识尚有很多不足。本文就胃癌来源的外泌体在腹膜转移细胞机制中的研究进展做简要综述。Gastric cancer is one of the most common cancers in the world,with more than 50%of the cases occurring in East Asia and the second highest mortality rate among all malignant tumors.Metastasis is the main reason for poor prognosis of gastric cancer due to its predisposition to peritoneal diffusion.Existing studies have suggested that exosomes are involved in peritoneal metastasis of gastric cancer,and exosomes can convey potential biological information to nearby or distant places,and destroy the mesothelial barrier by damaging peritoneal mesothelial cells,thus further causing peritoneal fibrosis and forming a metastasis environment conducive to peritoneal metastasis of gastric cancer.The role of exosomes in peritoneal metastasis of gastric cancer is still poorly understood.In this paper,we reviewed the research progress of exosomes derived from gastric cancer in the mechanism of peritoneal metastasis.

关 键 词：胃癌 外泌体 腹膜转移 腹膜间皮细胞 

分 类 号：R735.2[医药卫生—肿瘤]