Preservation of platelet function in patients with cirrhosis and thrombocytopenia undergoing esophageal variceal ligation  

作　　者：Evandro de Oliveira Souza Elbio Antonio D’Amico Tania Rubia Flores da Rocha Caroline Marcondes Ferreira Juliana Medeiros Batista Luiz Augusto CarneiroD’Albuquerque Flair Jose Carrilho Alberto Queiroz Farias 

机构地区：[1]Division of Gastroenterology and Hepatology,University of Sao Paulo School of Medicine,Av.Dr.Eneas Carvalho de Aguiar,255,9th floor,office 9159,Sao Paulo,SP 05403-000,Brazil [2]Hemostasis Laboratory,Hematology Service,University of Sao Paulo School of Medicine,Av.Dr.Eneas Carvalho de Aguiar,255,2nd floor,Sao Paulo,SP 05403-000,Brazil

出　　处：《Hepatobiliary & Pancreatic Diseases International》2020年第6期555-560,共6页国际肝胆胰疾病杂志（英文版）

摘　　要：Background:Thrombocytopenia is a possible risk factor for bleeding after band ligation of esophageal varices.However,elevated von Willebrand factor(VWF)in cirrhosis improves platelet function and could decrease this risk.Our objective was to assess platelet function in patients with cirrhosis undergoing esophageal variceal ligation(EVL).Methods:The assessment consisted of platelet count,antigen and activity of VWF and VWF-cleaving protease ADAMTS-13 activity,and a platelet adhesion and aggregation test simulating vascular flow in vivo(Impact-RR)prior to EVL.Results:Totally 111 patients were divided into three groups according to platelet count:(1)<50×109/L(n=38,34.2%);(2)50×109/L to 100×109/L(n=47,42.3%);and(3)>100×109/L(n=26,23.4%).No statistically significant difference was found in the aggregate size of platelets[group 1:41.0(31.8–67.3)μm 2;group 2:47.0(33.8–71.3)μm 2;and group 3:47.0(34.0–66.0)μm 2;P=0.60]and no significant correlation was found between aggregate size and platelet count(Spearman r=0.07;P=0.47).Surface coverage was 4.1%(2.8%–6.7%),8.5%(4.0%–10.0%),and 9.0%(7.1%–12.0%)(P<0.001)in groups 1,2 and 3,respectively and correlated with platelet count(Spearman r=0.39;P<0.0001).There was no significant difference between groups in VWF or ADAMTS-13.Post-EVL bleeding occurred in six(5.4%)patients(n=2 in group 1,n=1 in group 2,and n=3 in group 3;P=0.32).Patients with bleeding had higher MELD scores[15.0(11.3–20.3)versus 12.0(10.0–15.0);P=0.025],but no difference was demonstrated for platelet function parameters.Conclusion:Platelet function is preserved even in the presence of thrombocytopenia,including in the patients with post-EVL bleeding.

关 键 词：CIRRHOSIS HEMOSTASIS THROMBOCYTOPENIA Platelet aggregation Endoscopy Hemorrage 

分 类 号：R657.3[医药卫生—外科学] R558.2[医药卫生—临床医学]