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作 者:魏秀丽 崔进 李晴 张秀英[2] 冯言言 徐恩民 WEI Xiuli;CUI Jin;LI Qing;ZHANG Xiuying;FENG Yanyan;XU Enmin(Institute of Veterinary Drug Quality Inspection of Shandong Province,Shandong Engineering Laboratory for Durg Resistance Monitoring and Precise Drug Use of Animal Origin Bacteria,Shandong Engineering Laboratory for Chinese Traditional Medicine For A nim al,Shandong Provincial Key Laboratory of Quality Safety Monit oring and Risk Assessment for Animal Products,Jinan Shandong 250022,China;China Institute of Veterinary Medicine Inspection,Beijing 100081,China;Qilu Animal Healtli Products CO.,LTD,Jinan Shangdong 250100,China;Animal husbandry and Veterinary Bureau of Rizhao JüXian,JüXian Shangdong 276500,China)
机构地区:[1]山东省兽药质量检验所,动物源细菌耐药性监测与精准化用药山东省工程实验室,山东省动物用中药制剂工程实验室,山东省畜产品质量安全监测与风险评估重点实验室,山东济南250022 [2]中国兽医药品监察所,北京100081 [3]齐鲁动物保健品有限公司,山东济南250100 [4]山东省日照市莒县畜牧兽医局,山东莒县276500
出 处:《中兽医医药杂志》2020年第6期22-24,共3页Journal of Traditional Chinese Veterinary Medicine
基 金:2015年国家科技支撑计划“兽药安全与质量评价技术研究与应用”(BAD11B03-01);2019年山东省农业重大应用技术创新项目“蛋鸡安全生产关键技术集成创新与示范”(SD2019XM004)。
摘 要:探讨紫锥菊提取物与抗菌药物恩诺沙星联合用药对大肠杆菌体外抑菌作用。采用微量肉汤稀释法测定紫锥菊提取物和恩诺沙星分别单用和联合用药时对13株大肠杆菌的最小抑菌浓度(MIC),并计算联合用药指数。结果表明,联合用药作用于其中的10株大肠杆菌菌株,显示良好的协同或相加作用(FIC≤1);联合用药作用于其中的3株大肠杆菌菌株,显示无关作用(1<FIC≤2);联合用药未显示拮抗作用。说明紫锥菊提取物与恩诺沙星联合用药,对大肠杆菌的体外抑菌具有较强的协同作用,能显著降低恩诺沙星的用量。To investigate the synergistic effect of the combination of echinacea extract and enrofloxacin on the bacteriostatic effect of Escherichia coli in vitro.A micro broth dilution method was used to determine the minimum inhibitory concentration(mic)of 13 strains of E.coli when used alone and in combination with enrofloxacin,and calculated the combined drug use index.The results showed that the combined drug index of 10 strains of 13 strains was less than or equal to 1(FIC≤1),and it was determined that the combined drug had good synergistic or additive effect,3 strains showed that the combined drug had no significant effect(1<FIC≤2),and no strains showed that the combined drug had antagonistic effect.The results showed that the combination of echinacea extract and enrofloxacin had a strong synergistic effect on the bacteriostasis of E.coli in vitro,and could significantly reduce the dosage of enrofloxacin.
关 键 词:紫锥菊提取物 恩诺沙星 减抗 联合用药 最小抑菌浓度
分 类 号:S853.74[农业科学—临床兽医学]
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