睡眠时长、入睡时间与绝经后女性骨质疏松风险的相关性研究  

A correlational research between sleep duration,timing and the risk of osteoporosis in postmenopausal women

作　　者：杨嫣琼 张巧 彭年春 胡颖 张淼 徐淑静 王睿 时立新 Yang Yanqiong;Zhang Qiao;Peng Nianchun;Hu Ying;Zhang Miao;Xu Shujing;Wang Rui;Shi Lixin(Department of Endocrinology,Affiliated Hospital of Guizhou Medical University,Guiyang 550004,China)

机构地区：[1]贵州医科大学附属医院内分泌科,贵阳550004

出　　处：《中华内分泌代谢杂志》2020年第11期949-955,共7页Chinese Journal of Endocrinology and Metabolism

基　　金：国家卫生和计划生育委员会公益性行业科研专项(201502007);科技部国家重点研发计划精准医学专项(2016YFC0901203);贵州省临床重点专科培育项目(医政)(SZD-2016-01)。

摘　　要：目的探索睡眠时长、入睡时间与绝经后女性骨质疏松风险的相关性,探讨睡眠影响骨质疏松的可能机制,进一步指导骨质疏松的防治工作。方法本研究共筛选出5449名绝经后女性作为研究对象,对所有研究对象进行问卷调查、体格检查、血样检验、定量超声检测法测量骨密度,对潜在混杂因素进行调整后,用logistic回归模型评估睡眠时长、入睡时间与骨质疏松风险的关系。结果在绝经后女性人群中,不同骨质疏松风险人群的睡眠时长和入睡时间存在显著差异(P<0.05);调整年龄、BMI、糖尿病、高血压、血脂异常、吸烟、饮酒、运动后,睡眠时长≥9 h组与7~8 h组相比,骨质疏松风险升高(OR=1.39,95%CI 1.17~1.65,P<0.05);进一步联合睡眠时长及入睡时间分析不同睡眠习惯对骨质疏松风险的影响,与睡眠时长为7~8 h且入睡时间在22:00~23:00的人群相比,睡眠时长≥9 h且入睡时间为22:00~23:00人群骨质疏松风险升高(OR=1.38,95%CI 1.01~1.87,P<0.05),睡眠时长≥9 h且入睡时间≥23:00人群骨质疏松风险更高(OR=1.43,95%CI 1.01~2.01,P<0.05)。结论绝经后女性人群中,睡眠时长过长(≥9 h)且入睡时间较晚(≥22:00)是骨质疏松风险升高的危险因素,且入睡时间越晚导致骨质疏松风险升高的可能性越大。Objective To investigate the correlation between sleep duration,sleep timing and the risk of osteoporosis in postmenopausal women,to identify contributing mechanisms and guide the prevention and treatment of osteoporosis.Methods A total of 5449 postmenopausal women were included in this study.All participants completed questionnaires,medical examinations,blood test and the measurement of bone mineral density using calcaneal quantitative ultrasonography.After adjusting for potential confounders,logistic regression model was used to assess the association of sleep duration,sleep timing with the risk of osteoporosis.Results In postmenopausal women,there were significant differences in sleep duration and timing among groups with different risk of osteoporosis(P<0.05).After controlling ages,BMI,diabetes,hypertension,dyslipidemia,smoking,alcohol consumption and physical activity,sleep duration was correlated with the risk of osteoporosis,long sleep duration(≥9 h)increased the risk of osteoporosis(OR=1.39,95%CI 1.17-1.65,P<0.05)compared with the group with sleep duration of 7~8 hours.In analysis of the combined effect of sleep duration and sleep time on the risk of osteoporosis,compared with normal sleep duration(7-8 h)and normal sleep timing(22:00-23:00),long sleep duration(≥9 h)and normal sleep timing(22:00-23:00)increased the risk of osteoporosis(OR=1.38,95%CI 1.01-1.87,P<0.05),which was higher in the group of long sleep duration(≥9 h)and late sleep timing(≥23:00;OR=1.43,95%CI 1.01-2.01,P<0.05).Conclusion Long sleep duration(≥9 h)and late sleep timing(≥22:00)are risk factors for the increased risk of osteoporosis in postmenopausal women,the late sleep timing leads to the higher risk.

关 键 词：睡眠时长 入睡时间 骨密度 骨质疏松风险 绝经后女性 

分 类 号：R580[医药卫生—内分泌]