缬沙坦结构确证的建立  

Establishment of Valsartan Structural Elucidation

作　　者：陈文霞[1] 高浩凌 白妍 朱兰芳[1] 沈大冬[1] CHEN Wen-xia;GAO Hao-ling;BAI Yan;ZHU Lan-fang;SHEN Da-dong(Research&Development Center,Zhejiang Medicine Co.,Ltd.,Shaoxing 312500,China;Zhejiang Changhai Pharmaceutical Co.,Ltd.,Shaoxing 312300,China)

机构地区：[1]浙江医药股份有限公司研究院,浙江绍兴312500 [2]浙江昌海制药有限公司,浙江绍兴312300

出　　处：《化学试剂》2020年第11期1331-1335,共5页Chemical Reagents

摘　　要：缬沙坦是一种血管紧张素-Ⅱ(Angiotensin-Ⅱ)受体拮抗剂,具有疗效确切、降血压效果持久稳定、副作用小、耐受性良好的特点,是继钙离子拮抗剂和血管紧张素转化酶抑制剂(ACEI)之后另一类具有竞争力的降压药。通过紫外吸收光谱(UV)、红外吸收光谱(IR)、高分辨质谱(HRMS)、核磁共振波谱(1HNMR、13CNMR、DEPT135、1H-1H COSY、HMQC、HMBC)数据、热重分析法(TGA)和差示扫描量热法(DSC)对缬沙坦进行结构表征,并对其红外光谱和核磁共振波谱进行了详细的解析和归属。综合运用多种谱学方法确证了缬沙坦的结构,为其质量研究提供参考。Valsartan is an angiotensin-Ⅱ(Angiotensin-Ⅱ)receptor antagonist with definite curative effect,lasting and stable blood pressure lowering effect,low side effects,and good tolerance.It is a calcium ion antagonist and angiotensin invertase inhibitor(ACEI)is another competitive antihypertensive drug.Ultraviolet absorption spectrum(UV),infrared absorption spectrum(IR),high resolution mass spectrometry(HRMS),nuclear magnetic resonance(NMR)spectroscopy(1HNMR,13CNMR,DEPT135,1H-1H COSY,HMQC,HMBC)data and TGA/DSC confirmed the structure of valsartan,and analyzes and assigns its infrared spectrum and nuclear magnetic resonance spectrum in detail.A variety of spectroscopy methods are used to confirm the structure of valsartan and provide a reference for its quality research.

关 键 词：缬沙坦 抗高血压药 核磁共振 归属 结构确证 

分 类 号：O482.53[理学—固体物理]