维甲酸受体在食管胃癌前病变中的表达研究  

Expression of The Retinoic Acid Receptor in Precancerous Lesions of Esophagus or Stomach

作　　者：金哲[1] 崔少杰[1] 金建军[1] JIN Zhe;CUI Shao-jie;JIN Jian-jun(The First Affiliated Hospital,the College of Clinical Medicine of Henan University of Science and Technology,Luoyang 471003,China)

机构地区：[1]河南科技大学临床医学院,河南科技大学第一附属医院,河南洛阳471003

出　　处：《食管疾病》2020年第4期270-272,共3页Journal of Esophageal Diseases

基　　金：河南省医学科技攻关项目(201504018)。

摘　　要：目的调查食管或胃癌前病变组织中维甲酸受体的表达状况。方法研究分两组,观察组100例,经胃镜和活检诊断为慢性食管或胃黏膜炎症伴异型增生,可伴或不伴肠化生;对照组100例,经胃镜和活检诊断为单纯食管炎或慢性浅表性胃炎。符合入选标准的患者,胃镜检查后将所取标本固定,由同一组医师进行病理诊断,然后用免疫组化法检测组织中的维甲酸受体。结果对照组维甲酸受体的阳性率87.00%,观察组51.00%,明显低于对照组,差异有统计学意义(P<0.05)。异型增生程度不同,表达也不一样:轻度异型增生者维甲酸受体的阳性率48.00%,中度异型增生者43.75%,重度异型增生者33.33%,三组相比,差异有统计学意义(P<0.05)。合并肠化生者维甲酸受体的阳性率46.80%,不合并肠化生者49.05%,两组相比,差异无统计学意义(P>0.05)。结论癌前病变组织中维甲酸受体表达明显降低,且异型增生程度越重,表达越低。这有可能是食管癌、胃癌的发生机制之一。Objective To observe the expression of retinoic acid receptor in precancerous lesions of esophagus or stomach.Methods Gastroscopy and biopsy were both used in two groups:observing group,100 patients with PLES;control group,100 patients with chronic simple superficial gastritis or esophagitis.All the cases of two groups were underwent the pathological evaluation and immunohistochemical expression level test of retinoic acid receptors.Results The immunohistochemical expression level of retinoic acid receptors in control group(87.00%)was significantly higher than that in observing group(51.00%,P<0.05).The positive rate of retinoic acid receptor was 48.00%in mild dysplasia,43.75%in moderate dysplasia and 33.33%in severe dysplasia;the difference between the three groups was statistically significant(P<0.05).The positive rate of retinoic acid receptor was 46.80%in patients with intestinal metaplasia and 49.05%in patients without intestinal metaplasia(P>0.05).Conclusion The expression level of retinoic acid receptors in the patients with PLES is significantly lower;the more severe the dysplasia is,the lower level of retinoic acid receptors expresses.This may be one of the mechanisms of esophageal cancer and gastric carcinogenesis .

关 键 词：食管癌 胃癌 癌前病变 异型增生 肠化生 维甲酸受体 

分 类 号：R571[医药卫生—消化系统]