重组人生长激素治疗特发性矮小患儿的疗效及生长速率预测模型的建立  

The Curative Effect of Recombinant Human Growth Hormone on Children with Idiopathic Short Stature and Establishment of Growth Rate Prediction Model

作　　者：王煜娇 武苏[1] 袁雪雯[1] 朱子阳[1] 顾威[1] 刘倩琦[1] WANG Yu-jiao;WU Su;YUAN Xue-wen;ZHU Zi-yang;GU Wei;LIU Qian-qi(Department of Endocrine,Children's Hospital Affiliated to Nanjing Medical University,Nanjing,Jiangsu,210008,China)

机构地区：[1]南京医科大学附属儿童医院内分泌科,江苏南京210008

出　　处：《现代生物医学进展》2020年第22期4244-4248,共5页Progress in Modern Biomedicine

基　　金：江苏省自然科学基金项目(BK20191123)。

摘　　要：目的:探讨重组人生长激素(rhGH)对特发性矮小(ISS)患儿的治疗效果,并建立rhGH治疗后生长速率(GV)的预测模型。方法:回顾性分析确诊为ISS并应用rhGH治疗1年的130例患儿的疗效,以治疗12个月后的GV为因变量,采用多元逐步回归方法建立ISS患儿疗效的预测模型。结果:rhGH治疗6个月、12个月的身高、身高标准差分值(Ht SDS)均逐渐升高(P<0.05),治疗12个月的身高增长(△Ht)、GV低于治疗6个月(P<0.05)。治疗6个月、治疗12个月的GV均与初始治疗时的生活年龄(CA)、骨龄(BA)、身高、体重及垂体高度呈负相关(P<0.05)。将治疗12个月GV作为因变量,治疗前初始身高(X1)、治疗6个月GV(X2)被纳入方程建立预测模型:Y=7.631-0.035X1+0.567X2,R2=0.791,并通过内外部验证。结论:rhGH治疗对ISS患儿的身高增长具有良好效果,前6个月的效果更好。rhGH治疗后ISS患儿的GV与治疗前CA、BA、身高、体重及垂体高度呈负相关。治疗前的身高、治疗6个月的GV能够较好地预测治疗12个月的GV。Objective: To investigate the curative effect of recombinant human growth hormone(rhGH) on children with idiopathic short stature(ISS), and to establish a prediction model of growth rate(GV) after rhGH treatment. Methods: The therapeutic effect of130 children who were diagnosed as ISS and treated with rhGH for 1 year was analyzed retrospectively. The GV at12 months after treatment was taken as the dependent variable, and the multiple stepwise regression method was used to establish the predictive model of the curative effect of children diagnosed as ISS. Results: Height and height standard deviation score(Ht SDS) of 6 months and 12 months after rh GH treatment all increased gradually(P<0.05), while height growth(△Ht) and GV at 12 months after treatment were lower than those of 6 months after treatment(P<0.05). GV at 6 months and 12 months after treatment were negatively correlated with chronologic age(CA), bone age(BA), height, weight and pituitary height at the initial treatment(P<0.05). With GV at 12 months of treatment as the dependent variable, the initial height(X1) before treatment and GV(X2) at 6 months after treatment were included into the equation to establish the prediction model: Y=7.631-0.035 X1+0.567 X2, R^2=0.791, and the model was verified internally and externally. Conclusion:rh GH treatment has a good effect on the height growth of ISS children, and the effect is better in the first 6 months. GV of children with ISS after rhGH treatment are negatively correlated with CA, BA, height, weight and pituitary height before treatment. Height before treatment and GV at 6 months of treatment are better predictors of GV at 12 months of treatment.

关 键 词：重组人生长激素 特发性矮小 疗效 预测模型 

分 类 号：R179[医药卫生—妇幼卫生保健] R153.2[医药卫生—公共卫生与预防医学]