肝细胞生长因子基因修饰的间充质干细胞治疗肝损伤的研究进展  

Mesenchymal stem cells modified with hepatocyte growth factor gene in the treatment of liver injury

作　　者：修文丽 毛成刚[1] 杨晨宇 董蒨[1] Xiu Wenli;Mao Chenggang;Yang Chenyu;Dong Qian(Department of Pediatric Surgery,the Affiliated Hospital of Qingdao University,Shandong Provincial Key Laboratory of Digital Medicine and Computer-assisted Surgery,Shandong College Collaborative Innovation Center of Digital Medicine Clinical Treatment and Nutrition Health,Qingdao 266003,China)

机构地区：[1]青岛大学附属医院小儿外科山东省数字医学与计算机辅助手术重点实验室山东省数字医学临床治疗与营养健康协同创新中心,266003

出　　处：《中华细胞与干细胞杂志（电子版）》2020年第6期373-377,共5页Chinese Journal of Cell and Stem Cell（Electronic Edition）

基　　金：山东省青岛市科技攻关项目(20-4-1-5-nsh);山东省自然科学基金(ZR2017PH040)。

摘　　要：减轻肝脏损伤、促进肝脏修复和再生始终是肝脏疾病研究中的重点。间充质干细胞(MSCs)是众多具有组织修复和再生能力细胞中的明星细胞,合成的多种细胞因子经旁分泌途径发挥调控细胞生存,调节炎症反应,促进血管再生和减轻纤维化等多种生物学效应,肝细胞生长因子(HGF)便是重点细胞因子之一。基于HGF的信号调控作用,再结合MSCs的干细胞优势,HGF基因修饰间充质干细胞(HGF-MSCs)作为一种干细胞治疗新策略能够发挥“1+1>2”的效果。本文就HGF-MSCs在减轻和修复肝损伤中的研究进展作综述。Liver disease research has always focused on reducing the injury and promoting the repair and liver regeneration.Mesenchymal stem cells(MSCs)are useful for tissue repair and regeneration.MSCs synthesize various cytokines to regulate cell survival,inflammatory response,promote angiogenesis,and reduce fibrosis through a paracrine manner.Hepatocyte growth factor(HGF)is one of those cytokines with the signaling regulation effect,and MSCs modified with HGF gene(HGF-MSCs)as a new stem cell therapy strategy can play agreat role.This review provides insight into the advantages of HGF-MSCs in mitigating and repairing liver injury.

关 键 词：间充质干细胞 肝细胞生长因子 肝损伤 

分 类 号：R575[医药卫生—消化系统]