六味地黄丸联合丁苯酞胶囊治疗脑小血管病伴非痴呆型血管性认知障碍的临床研究  

Liuwei Dihuang pills combined with butylphthalide capsules for the treatment of cerebral small vessel diseases with non-dementia vascular cognitive impairment

作　　者：张现伟[1] 刘东生[1] 陈昕[1] 赵晶[1] 白永军 蒋玉倩 谢蓉[1] 连新福[1] Zhang Xianwei;Liu Dongsheng;Chen Xin;Zhao Jing;Bai Yongjun;Jiang Yuqian;Xie Rong;Lian Xinfu(Department of Encephalopathy and Internal Medicine,Zhuhai Hospital of Guangdong Provincial Hospital of Traditional Chinese Medicine,Zhuhai519000,China)

机构地区：[1]广东省中医院珠海医院脑病内科,519000

出　　处：《山西医药杂志》2020年第23期3198-3200,共3页Shanxi Medical Journal

基　　金：珠海市卫生和计划生育局立项课题(2017J005)。

摘　　要：目的评价六味地黄丸联合丁苯酞胶囊治疗脑小血管病伴非痴呆型血管性认知障碍(VCIND)的疗效。方法将120例符合VCIND患者分为治疗组和对照组,2组均给予二级预防和控制脑血管病危险因素治疗,治疗组给予六味地黄丸和丁苯酞胶囊治疗,对照组给予尼莫地平片治疗,治疗6个月。采用北京版蒙特利尔认知(MoCA)量表、简明智力状态检查(MMSE)量表、事件相关电位(P300)评估2组治疗前后评分和潜伏期的变化情况。结果经治疗后2组患者的MMSE、MoCA评分均有提高,P300潜伏期均缩短。在治疗后3个月时2组MMSE、MoCA评分差异无统计学意义(P>0.05),治疗6个月后MoCA评分明显提高,差异具有统计学意义(P<0.05),而MMSE评分、P300潜伏期差异无统计学意义(P>0.05)。治疗组在治疗后3个月、治疗后6个月与治疗前比较,MMSE、MoCA评分、P300潜伏期比较,差异均有统计学意义(P<0.05)。对照组治疗后MMSE、MoCA评分均提高,差异有统计学意义(P<0.05),P300潜伏期缩短,但差异无统计学意义(P>0.05)。结论六味地黄丸联合丁苯酞软胶囊能有效改善脑小血管病伴VCIND患者的认知功能,安全有效。而尼莫地平对VCIND也有一定疗效,但疗效不如六味地黄丸及丁苯酞胶囊联合治疗。Objective To evaluate the efficacy of Liuwei Dihuang pills combined with butylphthalide capsules in the treatment of cerebrovascular disease with non-dementia vascular cognitive impairment(VCIND).Methods One hundred and twenty patients with VCIND were divided into a treatment group and a control group.Both groups were treated with secondary prevention and control of cerebrovascular disease risk factors.The treatment group was treated with Liuwei Dihuang pills and butylphthalide capsules.The control group was given nimodipine.The tablets were administered for 6 months.The Beijing version of the Montreal Cognitive(MoCA)Scale,the Mini-Mental State Examination(MMSE)Scale,and the Event-Related Potential(P300)were used to evaluate changes in scores and latency before and after treatment.Results After treatment,the MMSE and MoCA scores of both groups increased,and the latency of P300 was shortened.However,there was no significant difference in MMSE and MoCA scores at 3 months after treatment(P>0.05),and the MoCA score increased significantly after 6 months of treatment(P<0.05),suggesting that the difference was statistically significant.There was no significant difference in MMSE score and P300 latency(P>0.05).There were significant differences in the MMSE,MoCA score,and P300 latency between the treatment group before and 3 months after treatment,and 6 months after treatment(P<0.05).The MMSE and MoCA scores of the control group increased,which was statistically significant(P<0.05);the latency of P300 was shortened,but the difference was not statistically significant(P>0.05).Conclusion Liuwei Dihuang pills combined with butylphthalide soft capsule can effectively improve the cognitive function of patients with cerebrovascular disease accompanied by VCIND,which is safe and effective.Nimodipine also has a certain effect on VCIND,but the effect is not as good as the combination treatment of Liuwei Dihuang pills and butylphthalide capsule.

关 键 词：脑血管障碍 认知障碍 丁苯酞胶囊 六味地黄丸 

分 类 号：R743[医药卫生—神经病学与精神病学] R749.13[医药卫生—临床医学]