多聚体类抗腹腔粘连材料体系的构建及应用进展  

Progress in preparation and application of polymers in the prevention of peritoneal adhesions

作　　者：颜帅[1,2] 乐音子[2] 曾莉[2] YAN Shuai;YUE Yinzi;ZENG Li(Suzhou TCM Hospital Affiliated to Nanjing University of Chinese Medicine,Suzhou 215009,China;Nanjing University of Chinese Medicine,Nanjing 210023,China)

机构地区：[1]南京中医药大学附属苏州市中医医院,江苏苏州215009 [2]南京中医药大学,江苏南京210023

出　　处：《广东药科大学学报》2020年第6期891-896,共6页Journal of Guangdong Pharmaceutical University

基　　金：中国博士后科学基金特别资助(2019T120448);国家自然科学基金面上项目(81673982);国家自然科学基金青年项目(81804098);江苏省自然科学基金青年项目(BK20180219);江苏省青年医学人才项目(QNRC2016255);苏州市院内青年课题(YQN2016003)。

摘　　要：术后腹腔粘连是外科手术的严重并发症,可导致腹部剧烈疼痛、不孕和潜在的致命性肠梗阻。在临床前研究或临床试验中,药物治疗和物理屏障装置作为重要的两种方法不同程度上预防和减少粘连的形成,然而尚无一种方法可完全预防粘连形成。众多研究团队期望通过药物联合物理隔膜发挥协同效应,显著抑制腹腔粘连。本文通过系统回顾聚合物系统在预防术后腹腔粘连中的作用,重点介绍近期国际在开发和应用聚合物药物释放系统(如微粒、水凝胶和混合系统)方面的研究。Peritoneal adhesions are serious complications of surgery,and can result in pain,infertility,and potentially lethal bowel obstruction.Pharmacotherapy and barrier devices have reduced adhesion formation to varying degrees in preclinical studies or clinical trials.However,complete prevention of adhesions remains to be accomplished.A large number of research teams have hypothesized that the limitations of the two approaches could be overcome by combining their strengths in the context of controlled drug delivery.Here we review the role of polymeric systems in the prevention of peritoneal adhesions,with an emphasis on our recent work in developing and applying polymeric drug delivery systems such as hydrogels,and hybrid systems for peritoneal use.

关 键 词：腹腔粘连 粘连屏障 药理学方法 微粒给药系统 水凝胶 

分 类 号：R649.9[医药卫生—外科学]