初诊鼻咽癌病人抑郁状态的相关因素研究  

Related factors of depression in newly diagnosed nasopharyngeal carcinoma patients

作　　者：冉启志 冉文 谭月[3] 朱宁[3] 吴绍勇[3] RAN Qizhi;RAN Wen;TAN Yue;ZHU Ning;WU Shaoyong(School of Medicine and Life Sciences,Chengdu University of Traditional Chinese Medicine,Chengdu,Sichuan 610041,China;Health Management Center,West China Hospital,Sichuan University,Chengdu,Sichuan 610041,China;Department of Head&Neck and Mammary Gland Oncology,West China Hospital,Sichuan University,Chengdu,Sichuan 610041,China)

机构地区：[1]成都中医药大学医学与生命科学学院,四川成都610041 [2]四川大学华西医院健康管理中心,四川成都610041 [3]四川大学华西医院头颈乳腺肿瘤科,四川成都610041

出　　处：《安徽医药》2021年第1期40-43,共4页Anhui Medical and Pharmaceutical Journal

基　　金：成都中医药大学“杏林学者”学科人才提升计划医院专项(2018yky13);四川省科技支撑计划(2015SZ0157)。

摘　　要：目的探讨初诊鼻咽癌病人抑郁状态的发生率及危险因素。方法收集2016年1月至2017年12月四川大学华西医院收治的122例鼻咽癌病人的临床资料,并对病人的性别、年龄、肿瘤分期(cTNM分期)、吸烟史、饮酒史、医疗费用来源、文化程度、癌性疼痛、睡眠状态、血清C反应蛋白(CRP)水平等可能影响其发生抑郁状态的相关因素进行单因素和多因素分析。结果122例初诊鼻咽癌病人中,有32例出现抑郁状态,抑郁状态的发生率为26.2%(32/122),其中男性17例,女性15例;单因素分析显示,病人年龄、性别、吸烟、疼痛、失眠及血清CRP水平升高与抑郁状态有关(P<0.05),多因素分析显示,鼻咽癌抑郁状态独立危险因素是年龄、吸烟、失眠、血清CRP水平升高(P<0.001)。结论初诊鼻咽癌病人抑郁状态的发生率较高。病人年龄、失眠、吸烟及CRP与初诊鼻咽癌病人抑郁状态独立危险因素。Objective To investigate the incidence and related factors of depression in newly diagnosed nasopharyngeal carcinoma(NPC).Methods The clinical data of 122 patients with NPC at West China Hospital of Sichuan University from January 2016 to December 2017 were collected,and the univariate and multivariate logistic regression analysis were carried out on the related factors of depression,such as gender,patient’s age,the cTNM staging,smoking history,drinking history,medical expense source,education,cancer pain,sleep state and serum CRP level.Results Of the 122 newly diagnosed NPC patients,32 cases had depression,and the incidence of depression was 26.2%(32/122),including 17 males and 15 females.Univariate analysis showed that depression was associated with patient’s age,gender,smoking,pain,insomnia and high serum CRP expression(P<0.05),multivariate logistic regression analysis showed that patient’s age,smoking,insomnia and high serum CRP expression were independent risk factors for depression(P<0.001).Conclusions The incidence of depression is higher in newly diagnosed nasopharyngeal carcinoma patients.Patient’s age,insomnia,smoking and high serum CRP expression are independent risk factors for depression in newly diagnosed NPC patients.It is necessary to strengthen the psychological evaluation and counseling for newly diagnosed NPC patients,and to strengthen the observation of the high-risk patients with insomnia,high serum CRP expression and smoking history,and to provide continuous and standardized psychosocial support to improve the psychological bearing capacity of patients.

关 键 词：鼻咽肿瘤 抑郁 危险因素 C反应蛋白 

分 类 号：R739.63[医药卫生—肿瘤]