老年性黄斑变性的性别相关性全球疾病负担  

Gender-related global disease burden in age-related macular degeneration

作　　者：王宝勇 王银歌 WANG Baoyong;WANG Yinge(Baoding Fourth Central Hospital Ophthalmology,Baoding,Hebei 072350,China)

机构地区：[1]保定市第四中心医院眼科,河北保定072350

出　　处：《安徽医药》2021年第1期184-187,共4页Anhui Medical and Pharmaceutical Journal

摘　　要：目的利用伤残调整生命年(disability-adjusted life yearDALY,DALY)探索性别与老年性黄斑变性(senile macular degeneration,SMD)全球疾病负担的关系及其对公共卫生政策的意义。方法通过进行一项国际性数据库观察研究,从全球健康数据交换(data exchange)数据库发表的"2018年全球疾病负担研究"中提取了1990年至2017年全球性别特定性SMD的疾病负担数值、粗略的疾病负担率和年龄标准化的疾病负担率,从而分析比较社会经济相关的性别差异对SMD疾病负担的影响。结果SMD引起的所有年龄段性别特异性全球疾病负担—伤残调整生命年数和伤残调整生命年率从1990—2017年处于上升趋势,其中女性的伤残调整生命年数由1990年的151958.39(95%UI:208911.03~102688.65)增加到2017年的307576.72(95%UI:421655.58~209694.25),男性的从1990年的102999.44(95%UI:142727.58~69913.40)到2017年的223157.46(306692.81~153280.42);女性的伤残调整生命年率为1990年5.68(95%UI:7.80~3.84)至2017年8.08(95%UI:11.08~5.51),男性为1990年3.79(95%UI:5.25~2.57)至2017年5.82(95%UI:8.00~4.00);女性年龄标准化的伤残调整生命年率从1990年的7.28(95%UI:10.00~4.92)下降到2017年7.16(95%UI:9.81~4.88),然而男性SMD的年龄标准化的伤残调整生命年率从1990年6.13(95%UI:8.47~4.15)到2000年出现短暂波动后,最终在2017年升高到6.26(95%UI:8.64~4.31)。曼—惠特尼检验显示,三者均呈现性别差异(P<0.01)。结论在过去的28年中,SMD导致的疾病负担总体处于上升趋势,女性的疾病负担比男性更大。本研究的发现有助于提高公共卫生部门对SMD全球疾病负担的关注,制定更优化的政策应对SMD的治疗。Objective To explore the relationship between gender and the global burden of Senile macular degeneration(SMD)by using Disability Adjusted Life Years(DALY)and its implications for public health policy.Methods An international database observation study was conducted to extract the global gender-specific SMD burden values,rough disease burden rates and age-standardized disease burden rates from 1990 to 2017 from t"2018 Global Burden of Disease Study"published by the Global Health Data Exchange database,and to analyze and compare the impact of socioeconomic related gender differences on SMD disease burden.Results The gender-specific global burden of disease,DALY and its rate in all age groups caused by age-related macular degeneration,were on the rise from 1990 to 2017.Among them,the disability-adjusted life years for women increased from 151958.39 in1990(95%UI:208911.03-102688.65)to 2017.In 2010,307576.72(95%UI:421655.58-209694.25)of males were from102999.44(95%UI:142727.58-69913.40)in 1990 to 223157.46(306692.81-153280.42)in 2017,and the disability-adjusted life-year rate of females was from 5.68(95%UI:7.80-3.84)in 1990 to 8.08(95%UI:11.08-5.51)in 2017.From 3.79(95%UI:5.25-2.57)in 1990 to 5.82(95%UI:8.00-4.00)in 2017,the age-standardized disability-adjusted life-span rate for women decreased from 7.28(95%UI:10.00-4.92)in 1990 to 7.16(95%UI:9.81-4.88)in 2017.However,age-standardized disability-adjusted lifespan rate for men with age-related macular degeneration was 7.16(95%UI:9.81-4.88).From 6.13 in 1990(95%UI:8.47-4.15)to2000,after a short fluctuation,it finally rose to 6.26(95%UI:8.64-4.31)in 2017.Mann-Whitney test showed that there were significant gender differences among the three groups(P<0.01).Conclusions In the past 28 years,the disease burden caused by agerelated SMD has been on the rise in general,and the disease burden of women is greater than that of men.The findings of this study will help to raise public health departments attention to the global burden of disease in age-related SMD and formulate mor

关 键 词：黄斑变性 生命统计 公共卫生管理 伤残调整生命年 疾病负担 

分 类 号：R774.5[医药卫生—眼科]