结直肠癌患者肿瘤静脉血CTCs和CEA mRNA水平对异时性肝转移的预测价值  

Detection of CTCs and CEA mRNA levels in tumor venous blood of patients with colorectal cancer for predicting metachronous liver metastasis

作　　者：程煌荣 郑勇斌[1] CHENG Huangrong;ZHENG Yongbin(Department of Gastrointestinal Surgery Division 1,Renmin Hospital of Wuhan University,Hubei Wuhan 430060,China)

机构地区：[1]武汉大学人民医院胃肠外科,湖北武汉430060

出　　处：《现代肿瘤医学》2021年第2期263-266,共4页Journal of Modern Oncology

摘　　要：目的:探讨检测结直肠癌患者肿瘤静脉血CTCs、CEA mRNA对异时性肝转移的预测价值。方法:选取2017年3月至2018年12月无同时性肝转移的结直肠癌患者75例,检测患者肿瘤静脉血CTCs和CEA mRNA水平,随访半年,分析CTCs和CEA mRNA水平与异时性肝转移和TNM分期的关系。结果:CTCs、CEA mRNA和两者联合检测预测异时性肝转移的敏感性分别为86.7%(13/15)、73.3%(11/15)、90.9%(10/11),特异性分别为90.0%(54/60)、83.3%(50/60)、92.2%(59/64);CTCs、CEA mRNA水平与TNM分期密切相关(P<0.05)。结论:结直肠癌异时性肝转移与肿瘤大小、浸润深度、分化程度、淋巴结转移、TNM分期有关;CTCs、CEA mRNA可检测肿瘤早期转移,作为结直肠癌异时性肝转移的预测指标;与单独检测CTCs和CEA mRNA水平相比,联合检测的敏感性与特异性更高,可为预测结直肠癌异时性肝转移提供更有价值的参考。Objective:To investigate the predictive value of separate detection of tumor venous blood circulation tumor cells(CTCs),carcinoembryonic antigen messenger ribonucleic acid(CEA mRNA)and combined detection in colorectal cancer patients for metachronous liver metastasis.Methods:The CTCs and CEA mRNA were detected in the tumor venous blood of 75 patients without liver metastasis and the correlation indexes of CTCs and CEA mRNA with metachronous liver metastasis and TNM staging were analyzed after half year follow-up.Results:The sensitivity of separate detection of CTCs,CEA mRNA andcombined detection to predict metachronous liver metastasis was 86.7%(13/15),73.3%(11/15)and 90.9%(10/11),respectively,and the specificity was 90.0%(54/60),83.3%(50/60)and 92.2%(59/64),respectively.CTCs,CEA mRNA levels are closely related to TNM staging(P<0.05).Conclusion:Metachronous liver metastasis is associated with tumor size,depth of tumor invasion,degree of tumor differentiation,lymph node metastasis and TNM staging.CTCs and CEA mRNA could be used as early predictors of metachronous liver metastasis from colorectal cancer.Combined detection of CTCs and CEA mRNA is more effective than separate.

关 键 词：结直肠癌 异时性肝转移 循环肿瘤细胞 癌胚抗原信使核糖核酸 

分 类 号：R735.3[医药卫生—肿瘤]