基于PQM脚本进行直肠癌放疗计划定量评价的研究与应用  

Research of quantitative evaluation of radiotherapy for rectal cancer based on PQM script

作　　者：贺睿敏 杨晓喻[2] 李书舟 杨振[2] 曹瑛 贺秋冬 肖若冰 HE Ruimin;YANG Xiaoyu;LI Shuzhou;YANG Zhen;CAO Ying;HE Qiudong;XIAO Ruobing(Department of Radiotherapy,the Second Affiliated Hospital,University of South China,Hunan Hengyang 421400,China;Radiotherapy Center,Department of Oncology,Xiangya Hospital,Central South University,Hunan Changsha 410005,China)

机构地区：[1]南华大学附属第二医院放射治疗科,湖南衡阳421400 [2]中南大学湘雅医院肿瘤科放射治疗中心,湖南长沙410005

出　　处：《现代肿瘤医学》2021年第2期331-334,共4页Journal of Modern Oncology

基　　金：国家自然科学基金青年科学基金项目(编号:61906215)。

摘　　要：目的:建立一个计划质量评估脚本,用于量化评估放疗计划,并验证该程序的临床可行性。方法:建立直肠癌计划质量测度标准(plan quality metrics,PQM),其中包含18个子测度(submetrics),使用C#语言在Visual Studio编辑器中构建脚本评估程序,对20例采用不同辐照技术的治疗计划分别通过脚本程序和Plan IQ软件(参照对象)进行评价打分,首先分析两种评估方法所得评分的差异然后进行两种辐照技术的得分对比,从而验证脚本程序的临床可行性。结果:使用脚本程序、Plan IQ这两种评估方法得出VMAT组和IMRT组靶区得分为(73.2±16.6)分和(56.8±14.9)分、(70.7±19.3)分和(63.1±11.5)分,差异具有统计学意义(P<0.05);危及器官(organ at risk,OAR)得分为(91.9±3.2)分和(80.4±8.5)分、(89.9±5.1)分和(75.1±11.0)分,差异具有统计学意义(P<0.05);总分得分为(84.1±8.1)分和(70.2±10.0)分、(84.6±5.9)分和(71.8±10.0)分,差异具有统计学意义(P<0.05)。对数据使用Bland-Altman分析,处于特定区间外的数据在数据总量中占比小于5%。结论:脚本评估程序可以针对计划质量进行客观的评估,可作为计划系统的评估应用程序。Objective:To build a plan quality metrics(PQM)assessment script to quantify the treatment plan and verify the feasibility of the script.Methods:A plan quality metrics with 18 submetrics for rectal cancer was established to build a assessment script in the Visual Studio with C#.Treatment plans with different delivery techniques was evaluated and scored by the script program and Plan IQ software respectively.First,the difference between the two evaluation methods was analyzed,and then the scores of the two delivery techniques were compared to verify the feasibility of the script.Results:In Script group and Plan IQ group,the target scores of the VMAT group and the IMRT group were(73.2±16.6)scores,(56.8±14.9)scores and(70.7±19.3)scores,(63.1±11.5)scores,and the difference was statistically significant(P<0.05).Scores of OAR were(91.9±3.2)scores,(80.4±8.5)scores and(89.9±5.1)scores,(75.1±11.0)scores,and the difference was statistically significant(P<0.05).Total scores were(84.1±8.1)scores,(70.2±10.0)scores and(84.6±5.9)scores,(71.8±10.0)scores,and the difference was statistically significant(P<0.05).In the comparative analysis of the data,the data outside the consistency interval accounted for<5%of the total.Conclusion:The script can evaluate the quality of treatment plan effectively and objectively,and can be used as the evaluation application for treatment planning system.

关 键 词：C# 计划质量测度 直肠癌 Plan IQ 

分 类 号：R730.55[医药卫生—肿瘤]