血浆置换联合分子吸附再循环系统治疗肝衰竭的疗效  

The Effect of Plasma Exchange Combined with Molecular Adsorption Recirculation System in the Treatment of Liver Failure

作　　者：郭婷[1] 王伟新[1] 张丽丽[1] GUO Ting;WANG Wei-xin;ZHANG Li-li(Department of Liver Diseases,Second Affiliated Hospital of Yichun University,Yichun 336000,Jiangxi,China)

机构地区：[1]宜春学院第二附属医院肝病科,江西宜春336000

出　　处：《医学信息》2020年第24期104-106,共3页Journal of Medical Information

摘　　要：目的研究血浆置换联合分子吸附再循环系统治疗肝衰竭临床效果。方法选取2019年3月~2020年9月我院治疗的42例肝衰竭患者为研究对象,采用随机数字表法分为观察组和对照组,各21例。对照组采用血浆置换治疗,观察组在对照组基础上联合应用分子吸附再循环系统治疗,比较两组临床治疗总有效率、肝功能指标、凝血功能指标、临床症状评分以及不良反应发生情况。结果观察组临床治疗总有效率为85.71%,高于对照组的66.67%,差异有统计学意义(P<0.05);治疗后,观察组ALT、AST、TBIL低于对照组,差异有统计学意义(P<0.05);观察组PT短于对照组,PLT计数大于对照组,差异有统计学意义(P<0.05);观察组临床纳差、乏力、恶心呕吐、腹胀各症状评分均低于对照组,差异有统计学意义(P<0.05);观察组不良反应发生率为9.52%,与对照组的14.28%比较,差异无统计学意义(P>0.05)。结论血浆置换联合分子吸附再循环系统治疗肝衰竭效果确切,可提高治疗总有效率,改善肝功能和凝血功能,减轻临床症状,且不增加不良反应发生几率。Objective To study the clinical effect of plasma exchange combined with molecular adsorption recirculation system in the treatment of liver failure.Methods A total of 42 patients with liver failure treated in our hospital from March 2019 to September 2020 were selected as the research objects,and they were divided into observation group and control group by random number table method,with 21 cases in each group.The control group was treated with plasma exchange,and the observation group was combined with molecular adsorption recirculation system treatment on the basis of the control group.The total effective rate of clinical treatment,liver function indexes,blood coagulation function indexes,clinical symptom scores and adverse reactions were compared between the two groups.Results The total effective rate of clinical treatment in the observation group was 85.71%,which was higher than 66.67% in the control group,the difference was statistically significant(P<0.05);after treatment,the observation group had lower ALT,AST and TBIL than the control group,the difference was statistically significant(P<0.05);PT of the observation group was shorter than that of the control group,and the PLT count was greater than that of the control group,the difference was statistically significant(P<0.05);the observation group's clinical anorexia,fatigue,nausea and vomiting,and abdominal distension were all lower than In the control group,the difference was statistically significant(P<0.05);the incidence of adverse reactions in the observation group was 9.52%,compared with 14.28% in the control group,the difference was not statistically significant(P>0.05).Conclusion Plasma exchange combined with molecular adsorption recirculation system has a definite effect in the treatment of liver failure.It can increase the total effective rate of treatment,improve liver function and coagulation function,reduce clinical symptoms,and does not increase the probability of adverse reactions.

关 键 词：血浆置换 分子吸附再循环系统 肝衰竭 

分 类 号：R575.3[医药卫生—消化系统]