RNA结合基序蛋白25在恶性肿瘤中的研究进展  

Research progress of RNA binding motif 25 in malignant tumors

作　　者：黎旺红 唐津天[1] 舒垠 刘晨 王瑞宾 王伯庆[1] LI Wanghong;TANG Jintian;SHU Yin;LIU Chen;WANG Ruibin;WANG Boqing(Department of Hepatobiliary and Pancreatic Surgery,Affiliated Cancer Hospital of Xinjiang Medical University,Xinjiang Uygur Autonomous Region,Urumqi830011,China)

机构地区：[1]新疆医科大学附属肿瘤医院肝胆胰外科,新疆乌鲁木齐830011

出　　处：《中国医药导报》2020年第35期53-56,共4页China Medical Herald

基　　金：新疆维吾尔自治区自然科学基金资助项目(2015211C126)。

摘　　要：RNA结合基序蛋白25(RBM25)属于RNA结合蛋白家族,其表达蛋白位于细胞核核斑点上,是一种剪切因子,参与基因的选择性剪切过程。近年来,RBM25对恶性肿瘤的影响引起了越来越多的学者关注。目前研究表明,RBM25表达量的高低与异常剪切对恶性肿瘤的发生、发展、转移及预后均有影响。本文就RBM25与急性髓系白血病、前列腺癌、人乳头瘤病毒阳性头颈部恶性肿瘤、乳腺癌、肺腺癌、骨肉瘤及结肠癌等多种恶性肿瘤的研究进展作一综述。RNA binding motif protein 25(RBM25)belongs to the RNA-binding protein family.It’s expressed proteins,located in nuclear spots,are shear factors and participate in the selective shearing process of genes.In recent years,more and more scholars have paid attention to the effect of RBM25 on malignant tumors.Current studies have shown that the high and low expression level of RBM25 and abnormal shear have an impact on the occurrence,development,metastasis and prognosis of malignant tumors.This paper reviews the research progress of RBM25 in diverse malignant tumors,such as acute myeloid leukemia,prostate cancer,human papillomavirus positive head and neck malignancies,breast cancer,lung adenocarcinoma,osteosarcoma and colon cancer and so on.

关 键 词：RNA结合基序蛋白25 恶性肿瘤 选择性剪切 剪切因子 

分 类 号：R73[医药卫生—肿瘤]