重组组织纤溶酶原激活剂静脉溶栓治疗对急性缺血性卒中患者MMSE评分的影响研究  

Effect of recombinant tissue plasminogen activator intravenous thrombolytic therapy on MMSE score in patients with acute ischemic stroke

作　　者：高吉祥 周天梅[1] GAO Jixiang;ZHOU Tianmei(Department of Neurology,Hangzhou Hospital of Traditional Chinese Medicine,Hangzhou310000,China)

机构地区：[1]杭州市中医院神经内科,浙江杭州310000

出　　处：《中国现代医生》2020年第31期30-33,共4页China Modern Doctor

基　　金：浙江省中医药科技计划项目(2015ZA152)。

摘　　要：目的探讨重组组织纤溶酶原激活剂(rt-PA)静脉溶栓治疗对急性缺血性卒中(AIS)患者简单智能精神状态(MMSE)评分的影响。方法回顾性分析2016年5月~2019年1月我院收治的78例急性AIS患者临床资料,按照入院顺序随机分为观察组与对照组,对照组给予丁苯酞与马来酸桂哌齐特,观察组在对照组基础上给予rt-PA静脉溶栓治疗,比较两组患者临床疗效、神经功能损伤、MMSE评分及并发症发生情况。结果观察组治疗总有效率为94.87%,显著高于对照组的74.36%(P<0.05);治疗后,两组患者不同时间点NIHSS评分均较治疗前下降,且观察组显著低于对照组(P<0.05);治疗后,两组患者不同时间点MMSE评分均较治疗前升高,且观察组显著高于对照组(P<0.05);两组患者牙龈出血、颅内出血和泌尿道出血发生率比较,差异均无统计学意义(P>0.05)。结论rt-PA静脉溶栓治疗急性AIS疗效显著,可减轻神经功能缺损症状,促进认知功能恢复,且能够减少并发症。Objective To investigate the effect of recombinant tissue plasminogen activator(rt-PA)intravenous thrombolytic therapy on mini-mental state examination(MMSE)score in patients with acute ischemic stroke(AIS).Methods The clinical data of 78 patients with acute AIS admitted to our hospital from May 2016 to January 2019 were retrospectively analyzed.The patients were randomly divided into observation group and control group according to the order of admission.The control group was given butylphthalide and cinepazide maleate.The observation group was given rt-PA intravenous thrombolytic therapy on the basis of the treatment in the control group.The clinical efficacy,neurological impairment,MMSE score and complications of the two groups were compared.Results The total effective rate of observation group was 94.87%,significantly higher than that of the control group(74.36%)(P<0.05).After treatment,the NIHSS scores of the two groups were lower than those before treatment,and the NIHSS score of the observation group was significantly lower than that of the control group(P<0.05).The MMSE scores of the two groups after treatment were higher than those before treatment,and the MMSE score of the observation group was significantly higher than that of the control group(P<0.05).There was no significant difference in the incidence of gingival hemorrhage,intracranial hemorrhage and urinary tract bleeding in the two groups(P>0.05).Conclusion rt-PA intravenous thrombolysis is effective in the treatment of acute AIS,which can alleviate the symptoms of neurological deficits,promote the recovery of cognitive function,and reduce complications.

关 键 词：重组组织纤溶酶原激活剂 静脉溶栓 急性缺血性卒中 简单智能精神状态评分 

分 类 号：R743.3[医药卫生—神经病学与精神病学]