72例癫痫合并妊娠患者临床特征分析  

Analysis of clinical characteristics of 72 epileptic patients with pregnancy

作　　者：冯红选 桂千 奚晓雪[2] 吴冠会[1] 朱伟[1] 董晓峰 程庆璋 沈明强 赵慧敏 侯晓夏 徐勤荣 王薇[1] FENG Hong-xuan;GUI Qian;XI Xiao-xue(Department of Neurology,Suzhou Municipal Hospital,Soochow 215002,China)

机构地区：[1]南京医科大学附属苏州市立医院神经内科,215002 [2]南京医科大学附属苏州市立医院妇产科,215002

出　　处：《临床神经病学杂志》2020年第6期462-464,共3页Journal of Clinical Neurology

基　　金：苏州市临床重点病种(LCZX201811);苏州市“科教兴卫”青年科技项目(KJXW2019029);CAAE癫痫科研基金--UCB基金(2020004B)。

摘　　要：目的探讨癫痫合并妊娠患者妊娠期间癫痫发作、抗癫痫药物使用情况、妊娠结局、分娩方式以及分娩后喂养情况,为癫痫合并妊娠患者的优生优育提供科学依据。方法分析2013年7月至2019年7月南京医科大学附属苏州医院门诊及住院的癫痫合并妊娠患者,分析患者妊娠期间癫痫发作、服用药物情况、妊娠结局、分娩方式以及喂养情况。结果共纳入72例患者,Ⅰ级38例(52.8%),Ⅱ级13例(18.1%),Ⅲ级15例(20.8%),Ⅳ级6例(8.3%)。60例(83.3%)妊娠期间服用抗癫痫药物治疗,12例(16.7%)未服用药物。其中54例(90%)患者采取单药治疗,6例(10%)采取联合用药治疗。65例(90.2%)孕早期服用叶酸。妊娠早期流产8例(11.1%)。64例正常妊娠中,子代畸形率1.5%(1/64)。剖宫产率57.1%(36/63),自然分娩42.9(27/63)。母乳喂养率46%(29/63)。结论癫痫合并妊娠患者妊娠期抗癫痫药物、分娩及喂养方式等管理有待进步一提高。Objective To explore the status of epileptic seizures during pregnancy,the use of antiepileptic drugs,the outcome of pregnancy,the mode of delivery and the feeding after delivery,so as to provide scientific basis for the eugenics and eugenics of epileptic pregnancy.Methods Patients with epilepsy and pregnancy in Suzhou Hospital Affiliated to Nanjing Medical University from July 2013 to July 2019 were analyzed retrospectively.The seizure,medication,pregnancy outcome,delivery mode and feeding were analyzed.Results In 72 patients,38 cases were gradeⅠ(52.8%),13 cases were gradeⅡ(18.1%),15 cases were gradeⅢ(20.8%),6 cases were gradeⅣ(8.3%).Sixty cases(83.3%)took antiepileptic medicine during pregnancy,12 cases(16.7%)did not take medicine.Fifty-four cases(90%)took single medicine,6 cases(10%)took combined medicine.Sixty-five cases(90.2%)took folic acid in early pregnancy.Eight cases(11.1%)had abortion in early pregnancy.Sixty-four cases had normal pregnancy,the deformity rate of offspring was 1.5%(1/64).The rate of cesarean section was 57.1%(36/63),and spontaneous delivery was 42.9(27/63).The breastfeeding rate was 46%(29/63).Conclusion The management of antiepileptic drugs,delivery and feeding methods in pregnancy should be improved.

关 键 词：癫痫 抗癫痫药物 妊娠 妊娠结局 

分 类 号：R742.1[医药卫生—神经病学与精神病学]