非鳞非小细胞肺癌基因检测技术研究进展  

Advances in gene detection techniques for non-squamous non-small cell lung cancer

作　　者：杨柳 赵君慧[1] YANG Liu;ZHAO Junhui(Qinghai University,Qinghai Xining 810000,China)

机构地区：[1]青海大学,青海西宁810000

出　　处：《现代肿瘤医学》2021年第1期172-176,共5页Journal of Modern Oncology

基　　金：青海省科技计划项目(编号:2018-ZJ-T02)。

摘　　要：随着分子生物学技术的日益发展,基于基因检测指导下的精准医疗已成为非鳞非小细胞肺癌的主要诊治模式。目前临床应用较广的基因检测技术大致分为:基因芯片(gene chip)技术、二代测序技术(next generation sequencing technologies,NGS)、扩增阻滞突变系统(amplification refractory mutation system,ARMS)、Cobas、数字聚合酶链反应(digital polymerase chain reaction,dPCR)和荧光原位杂交技术(fluorescence in situ hybridization,FISH)等,这些技术各有独特的优势与不足,本文综述不同基因检测技术在非鳞非小细胞肺癌临床应用中的研究进展。With the increasing development of molecular biology technology,precision medicine guided by genetic testing has become the main diagnosis and treatment mode of non-squamous non-small cell lung cancer.At present,the gene detection technologies widely used in clinical practice are broadly divided into:Gene chip technology,next generation sequencing technologies(NGS),amplification refractory mutation system(ARMS),Cobas,digital polymerase chain reaction(dPCR),and fluorescence in situ hybridization(FISH).These technologies have unique advantages and disadvantages.This article reviews the progress in the clinical application of different gene detection technologies in non-squamous non-small cell lung cancer.

关 键 词：非鳞非小细胞肺癌 基因检测技术 研究进展 

分 类 号：R734.2[医药卫生—肿瘤]