胆汁酸及其受体与腹泻型肠易激综合征的相关研究进展  

Research progress of bile acids and their receptors in irritable bowel syndrome with predominant diarrhea

作　　者：魏薇[1,2] 姚树坤 WEI Wei;YAO Shukun(Chinese Academy of Medical Sciences,Peking Union Medical College,Beijing 100032;Department of Gastroenterology,China-Japan Friendship Hospital,China)

机构地区：[1]中国医学科学院北京协和医学院,北京100032 [2]中日友好医院消化内科

出　　处：《胃肠病学和肝病学杂志》2020年第12期1420-1424,共5页Chinese Journal of Gastroenterology and Hepatology

摘　　要：胆汁酸在肠道中有重要作用,对肠道动力、肠屏障功能、肠道炎症状态、内脏敏感性方面均有影响。已发现腹泻型肠易激综合征(irritable bowel syndrome with predominant diarrhea,IBS-D)患者存在胆汁酸代谢异常,患者排便频率、排便性状、腹痛等症状与胆汁酸有相关性,且患者肠道的胆汁酸受体表达可能与健康对照者存在差异。现对胆汁酸及其受体与IBS-D的相关研究作一综述。Bile acids play an important part in the intestine,affecting intestinal motility,integrity of intestinal barrier,gut inflammation,and visceral sensitivity.Abnormalities of bile acids metabolism have been found in patients with irritable bowel syndrome with predominant diarrhea(IBS-D),which are correlated with stool frequency,stool consistency and abdominal pain,and the expression of bile acids receptors in the gut of IBS-D patients may be distinct from that in the gut of healthy controls.In this review,we discuss the role of bile acids and their receptors in the pathogenesis of IBS-D.

关 键 词：腹泻型肠易激综合征 胆汁酸 肠道动力 内脏高敏感 

分 类 号：R574[医药卫生—消化系统]