奥美拉唑与泮托拉唑治疗颅脑损伤并发应激性消化道出血患者的效果比较  

Comparison of the effect between Omeprazole and Pantoprazole in the treatment of patients with craniocerebral injury and stress gastrointestinal bleeding

作　　者：邓启亮[1] 邓永胜[1] 邹文雄 王李妮 陈伟 彭庆明[1] 刘娟妹[1] DENG Qi-liang;DENG Yong-sheng;ZOU Wen-xiong;WANG Li-ni;CHEN-Wei;PENG Qing-ming;LIU Juan-mei(Department of Gastroenterology,Ji'an Central People's Hospital,Jiangxi Province,Ji'an 343000,China)

机构地区：[1]江西省吉安市中心人民医院消化内科,江西吉安343000

出　　处：《中国当代医药》2020年第35期40-43,共4页China Modern Medicine

基　　金：江西省卫健委科技计划(指导性计划)项目(20187305)。

摘　　要：目的探讨奥美拉唑与泮托拉唑治疗颅脑损伤并发应激性消化道出血患者的效果。方法选取吉安市中心人民医院2018年1月~2019年6月收治的94例颅脑损伤并发应激性消化道出血患者作为研究对象,按照随机数字表法分为研究组(47例)和对照组(47例),对照组采用泮托拉唑治疗方法,研究组采用奥美拉唑与泮托拉唑治疗方法。比较两组的治疗总有效率、血清胃泌素、血红蛋白、止血时间和输血量。结果研究组总有效率高于对照组,差异有统计学意义(P<0.05);两组治疗前胃泌素和血红蛋白指标比较,差异无统计学意义(P>0.05);治疗后,两组的胃泌素低于治疗前,血红蛋白高于治疗前,且研究组的胃泌素低于对照组,血红蛋白高于对照组,差异有统计学意义(P<0.05)。研究组止血时间短于对照组,差异有统计学意义(P<0.05);研究组输血量少于对照组,差异有统计学意义(P<0.05)。结论应用奥美拉唑与泮托拉唑治疗颅脑损伤并发应激性消化道出血患者效果显著,可有效防止应激性消化道出血,降低胃泌素水平,还可以缩短止血时间,减少输血量,有利于患者尽快康复,值得大力推广。Objective To investigate the effect between Omeprazole and Pantoprazole in the treatment of patients with craniocerebral injury complicated with stress gastrointestinal bleeding.Methods A total of 94 patients with craniocerebral injury and stress gastrointestinal bleeding admitted to Ji'an Central People's Hospital from January 2018 to June 2019 were selected as the research objects,according to random number table method,they were divided into research group(47 cases)and control group(47 cases).The control group was treated with Pantoprazole and the study group was treated with Omeprazole and Pantoprazole.The therapeutic effect,serum gastrin,hemoglobin,hemostasis time and blood transfusion volume of the two groups were compared.Results The curative effect of the study group was higher than that of the control group,the difference was statistically significant(P<0.05).There were no statistically significant differences between the two groups in gastrin and hemoglobin before treatment(P>0.05).After treatment,the gastrin of the two groups was lower than that before treatment,the hemoglobin was higher than that before treatment,and the gastrin of the study group was lower than that of the control group,the hemoglobin was higher than that of the control group,the differences were statistically significant(P<0.05).The hemostasis time of the study group was shorter than that of the control group,and the difference was statistically significant(P<0.05).The blood transfusion volume of the study group was less than that of the control group,and the difference was statistically significant(P<0.05).Conclusion Omeprazole and Pantoprazole have a significant therapeutic effect on patients with craniocerebral injury complicated with stress gastrointestinal bleeding.It can not only reduce serum gastrin level and improve hemoglobin index,but also shorten the time of hemostasis and reduce the amount of blood transfusion,which is conducive to the recovery of patients as soon as possible.Therefore,it is worth promoting vigorously.

关 键 词：奥美拉唑 颅脑损伤 应激性消化道出血 胃泌素 

分 类 号：R573.2[医药卫生—消化系统]