α核素用于放射治疗:从基础放射化学到临床研究(第二部分)  

α-emitters for radiotherapy:from basic radiochemistry to clinical studies-part 2

作　　者：Sophie Poty Lynn C.Francesconi Michael R.McDevitt Michael J.Morris Jason S.Lewis 杨晖[7] 关志伟(译)[7] 徐白萱(审校)[7] Sophie Poty;Lynn C.Francesconi;Michael R.McDevitt;Michael J.Morris;Jason S.Lewis;Yang Hui;Guan Zhiwei;Xu Baixuan(Department of Radiology and Program in Molecular Pharmacology,Memorial Sloan Kettering Cancer Center,New York,New York;Department of Chemistry,Hunter College,New York,New York;Graduate Center of City University of New York,New York,New York;Department of Radiology,Weill Cornell Medical College,New York,New York;Department of Medicine,Memorial Sloan Kettering Cancer Center,New York,New York;Departments of Radiology and Pharmacology,Weill Cornell Medical College,New York,New York;不详)

机构地区：[1]Department of Radiology and Program in Molecular Pharmacology,Memorial Sloan Kettering Cancer Center,New York,New York [2]Department of Chemistry,Hunter College,New York,New York [3]Graduate Center of City University of New York,New York,New York [4]Department of Radiology,Weill Cornell Medical College,New York,New York [5]Department of Medicine,Memorial Sloan Kettering Cancer Center,New York,New York [6]Departments of Radiology and Pharmacology,Weill Cornell Medical College,New York,New York [7]解放军总医院第一医学中心核医学科,北京100853

出　　处：《中华核医学与分子影像杂志》2020年第12期761-768,共8页Chinese Journal of Nuclear Medicine and Molecular Imaging

摘　　要：利用放射源将具有细胞毒性的电离辐射作用到病灶处的方法可以追溯到20世纪初,起源于镭的发现及其能够产生的生理作用。α核素在放射治疗应用于临床肿瘤学领域中备受关注。该综述的第一部分探讨了基本的放射化学、高细胞杀伤效力和α核素的可应用性,以及存在于放射性标记方法和子核再分布的阻碍。该综述的第二部分将概述α核素在临床前和临床研究中最有希望和最新的用途。

关 键 词：放射治疗 α核素 放射化学 临床试验 

分 类 号：R73[医药卫生—肿瘤]