miR-378初始体rs1076064多态性与中国汉族人群乳腺癌的关联研究  

Association between rs1076064 in primary miR-378 and risk of breast cancer in Han Chinese population

作　　者：赵敏君 钱瑞仪 黄鑫[4] 杨阳[4] 陈科润 易维 杨瑞卿 司马秀田[2] ZHAO Min-jun;QIAN Rui-yi;HUANG Xin(West China School of Medicine,Sichuan University,Chengdu 610041,China)

机构地区：[1]四川大学华西医院全科医学科,四川成都610041 [2]四川大学华西医院神经外科,四川成都610041 [3]四川大学华西临床医学院,四川成都610041 [4]乐山市人民医院检验科,四川乐山614000

出　　处：《中国实验诊断学》2020年第12期1931-1934,共4页Chinese Journal of Laboratory Diagnosis

基　　金：四川省科技厅重点研发项目(2018SZ0216);四川大学青年教师科研启动基金(2017scu11038)。

摘　　要：目的探讨miR-378初始体rs1076064多态性与中国汉族女性乳腺癌发病的关联。方法运用二代测序技术分析miR-378初始体rs1076064多态性在乳腺癌(n=133)和健康对照人群(n=216)中的分布频率;运用SPSS25.0统计软件包处理数据。结果在共显性、显性和隐性遗传模型中,rs1076064多态性与乳腺癌发病无相关性(TC与TT相比,OR=1.15,95%CI:0.67-1.95;CC与TT相比,OR=1.35,95%CI:0.73-2.52;TC/CC与TT相比,OR=1.21,95%CI:0.73-2.00;CC与TT/TC相比,OR=1.24,95%CI:0.74-2.05)。亦未发现rs1076064多态性与乳腺癌肿瘤大小和淋巴结转移等临床特征之间存在相关性。结论miR-378初始体rs1076064可能不是中国汉族人群乳腺癌发病的易感位点。Objective To investigate the association between rs1076064 in primary miR-378 and risk of breast cancer in Han Chinese women.Methods The distribution frequency of rs1076064 in primary miR-378 was analyzed using Ion PGM sequencing among patients with breast cancer(n=133)and healthy controls(n=216).All data were performed using SPSS 25.0.Results There were no significant associations between rs1076064 and risk of breast cancer under co-dominant,dominant and recessive genetic models(TC vs.TT,OR=1.15,95%CI:0.67-1.95;CC vs.TT,OR=1.35,95%CI:0.73-2.52;TC/CC vs.TT,OR=1.21,95%CI:0.73-2.00;CC vs.TT/TC,OR=1.24,95%CI:0.74-2.05).Nor the association was observed between rs1076064 and tumor size and lymph node metastasis of breast cancer.Conclusion The rs1076064 in the primary miR-378 may not be a susceptibility locus for the development of breast cancer.

关 键 词：微小RNA-378初始体 乳腺癌 单核苷酸多态性 

分 类 号：R737.9[医药卫生—肿瘤]